Evidence map›Paper›PMID 31416192›Full record

ReviewInternational journal of molecular sciences2019

Understanding the Mechanisms of Resistance in

Marzia Del Re, Stefania Crucitta, Giulia Gianfilippo, Antonio Passaro, Iacopo Petrini, Giuliana Restante, Angela Michelucci, Stefano Fogli, Filippo de Marinis, Camillo Porta and 2 more

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. CanBMJ open · 2021
    Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Unravelling the complexity ofTranslational lung cancer research · 2025
    Article
  9. Liquid Biopsy in the Clinical Management of Cancers.International journal of molecular sciences · 2024
    Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Marzia Del ReUnit of Clinical Pharmacology and Pharmacogenetics, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy. marzia.delre@gmail.com.ORCID 0000-0001-7343-6161
Stefania CrucittaUnit of Clinical Pharmacology and Pharmacogenetics, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
Giulia GianfilippoUnit of Clinical Pharmacology and Pharmacogenetics, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
Antonio PassaroDivision of Thoracic Oncology, European Institute of Oncology, 20141 Milano, Italy.ORCID 0000-0002-7575-3870
Iacopo PetriniGeneral Pathology, Department of Translational Research & New Technologies in Surgery and Medicine, University of Pisa, 56126 Pisa, Italy.
Giuliana RestanteUnit of Clinical Pharmacology and Pharmacogenetics, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0002-6748-5562
Angela MichelucciUnit of Molecular Genetics, Department of Laboratory Medicine, University Hospital, 56126 Pisa, Italy.
Stefano FogliUnit of Clinical Pharmacology and Pharmacogenetics, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
Filippo de MarinisDivision of Thoracic Oncology, European Institute of Oncology, 20141 Milano, Italy.
Camillo PortaDepartment of Internal Medicine, University of Pavia, 27100 Pavia, Italy.
Antonio ChellaUnit of Respiratory Medicine, Department of Critical Area and Surgical, Medical and Molecular Pathology, University Hospital, 56126 Pisa, Italy.ORCID 0000-0002-4325-759X
Romano DanesiUnit of Clinical Pharmacology and Pharmacogenetics, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0002-4414-8934

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liquid biopsy has emerged as an alternative source of nucleic acids for the management of Epidermal Growth Factor Receptor (

Indexed as

AnimalsBiomarkers, TumorCarcinoma, Non-Small-Cell LungCirculating Tumor DNAClinical Decision-MakingDisease ManagementDrug Resistance, NeoplasmErbB ReceptorsHumansLiquid BiopsyLung NeoplasmsMolecular Targeted TherapyMutationProtein Kinase InhibitorsBiomarkers, TumorCirculating Tumor DNAEGFR protein, humanErbB ReceptorsProtein Kinase Inhibitorscirculating cell-free DNAepidermal growth factor receptorliquid biopsymechanisms of resistancenon-Small Cell Lung Cancertyrosine kinase inhibitors

Identifiers

PMID31416192
PMCPMC6720634

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.