Evidence map›Paper›PMID 31416117›Full record

ArticleMolecules (Basel, Switzerland)2019

Synthesis and Antiproliferative Activity of Novel A-Ring Cleaved Glycyrrhetinic Acid Derivatives.

Daniela P S Alho, Jorge A R Salvador, Marta Cascante, Silvia Marin

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Daniela P S AlhoLaboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal.ORCID 0000-0003-1564-6528
Jorge A R SalvadorLaboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal. salvador@ci.uc.pt.
Marta CascanteDepartment of Biochemistry and Molecular Biomedicine, Faculty of Biology, University of Barcelona, Diagonal 643, 08028 Barcelona, Spain.
Silvia MarinDepartment of Biochemistry and Molecular Biomedicine, Faculty of Biology, University of Barcelona, Diagonal 643, 08028 Barcelona, Spain. silviamarin@ub.edu.ORCID 0000-0003-0693-2207
Centro de Neurociências e Biologia Celular · PTInstituto de Salud Carlos III · ES

Funding

MOLECULAR PROBES OF CELL SURFACE PHENOMENAK04CA001033 · NCI · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI LOEW, LESLIE M · 1985 to 1985
–
Agència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR)-Generalitat de Catalunya 2017SGR1033FEDER and FCT REEQ/481/QUI/2006, RECI/QEQ-FI/0168/2012, and CENTRO-07-CT62-FEDER-002012FEDER (Programa Operacional Factores de Competitividade-COMPETE 2020) Projecto Estratégico: UID/NEU/04539/2013Fundação para a Ciência e Tecnologia (FCT) PhD grant SFRH/BD/66020/2009MINECO-European Commission FEDER-Una manera de hacer Europa SAF2017-89673-R(Programa Operacional do Centro 2020) PT2020 project nº 3269
6 · The paper itself

Abstract

A series of new glycyrrhetinic acid derivatives was synthesized via the opening of its ring A along with the coupling of an amino acid. The antiproliferative activity of the derivatives was evaluated against a panel of nine human cancer cell lines. Compound

Indexed as

Antineoplastic AgentsApoptosisCell Cycle CheckpointsCell Line, TumorCell ProliferationDose-Response Relationship, DrugGlycyrrhetinic AcidHumansMolecular StructureStructure-Activity RelationshipAntineoplastic AgentsGlycyrrhetinic Acidantiproliferative activityapoptosisA-ring cleaved derivativescell cycle arrestglycyrrhetinic acidpentacyclic triterpenoids

Identifiers

PMID31416117
PMCPMC6721064
OpenAlexW2967684586

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.