Observational studyPediatric neurosurgery2019
Magnetic Resonance Fingerprinting to Characterize Childhood and Young Adult Brain Tumors.
Observational study in Pediatric neurosurgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- A MR Fingerprinting Development Kit for Quantitative 3D Brain Imaging.Journal of magnetic resonance imaging : JMRI · 2026Article
- Research Progress on Glioma Microenvironment and Invasiveness Utilizing Advanced Multi-Parametric Quantitative MRI.Cancers · 2024Review
- Magnetic resonance relaxometry in quantitative imaging of brain gliomas: A literature review.The neuroradiology journal · 2024Review
- A Comparison of 7 Tesla MR Spectroscopic Imaging and 3 Tesla MR Fingerprinting for Tumor Localization in Glioma Patients.Cancers · 2024Article
- Advances in Neuro-Oncological Imaging: An Update on Diagnostic Approach to Brain Tumors.Cancers · 2024Review
- Advanced MR Techniques for Preoperative Glioma Characterization: Part 1.Journal of magnetic resonance imaging : JMRI · 2023Review
- Accuracy, repeatability, and reproducibility of TEuropean radiology · 2023Article
- Novel 3D magnetic resonance fingerprinting radiomics in adult brain tumors: a feasibility study.European radiology · 2023Article
- Article
- Quantitative Relaxometry Metrics for Brain Metastases Compared to Normal Tissues: A Pilot MR Fingerprinting Study.Cancers · 2022Article
- Technical overview of magnetic resonance fingerprinting and its applications in radiation therapy.Medical physics · 2022Review
- Characterization of pediatric brain tumors using pre-diagnostic neuroimaging.Frontiers in oncology · 2022Article
- A Magnetic Resonance-Relaxometry-Based Technique to Identify Blood Products in Brain Parenchyma: An Experimental Study on a Rabbit Model.Frontiers in veterinary science · 2022Article
- Magnetic resonance fingerprinting residual signals can disassociate human grey matter regions.Brain structure & function · 2022Article
- Magnetic resonance fingerprinting: an overview.European journal of nuclear medicine and molecular imaging · 2021Review
- Magnetic Resonance Fingerprinting of the Pediatric Brain.Magnetic resonance imaging clinics of North America · 2021Review
- Whole-brain 3D MR fingerprinting brain imaging: clinical validation and feasibility to patients with meningioma.Magma (New York, N.Y.) · 2021Article
- Review
- Feasibility of MR fingerprinting using a high-performance 0.55 T MRI system.Magnetic resonance imaging · 2021Article
- Multi-site, multi-platform comparison of MRI T1 measurement using the system phantom.PloS one · 2021Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
Abstract
objectMagnetic resonance fingerprinting (MRF) allows rapid, simultaneous mapping of T1 and T2 relaxation times and may be an important diagnostic tool to measure tissue characteristics in pediatric brain tumors. We examined children and young adults with primary brain tumors to determine whether MRF can discriminate tumor from normal-appearing white matter and distinguish tumor grade.
methodsMRF was performed in 23 patients (14 children and 9 young adults) with brain tumors (19 low-grade glioma, 4 high-grade tumors). T1 and T2 values were recorded in regions of solid tumor (ST), peritumoral white matter (PWM), and contralateral white matter (CWM). Nonparametric tests were used for comparison between groups and regions.
resultsMedian scan time for MRF and a sequence for tumor localization was 11 min. MRF-derived T1 and T2 values distinguished ST from CWM (T1: 1,444 ± 254 ms vs. 938 ± 96 ms, p = 0.0002; T2: 61 ± 22 ms vs. 38 ± 9 ms, p = 0.0003) and separated high-grade tumors from low-grade tumors (T1: 1,863 ± 70 ms vs. 1,355 ± 187 ms, p = 0.007; T2: 90 ± 13 ms vs. 56 ± 19 ms, p = 0.013). PWM was distinct from CWM (T1: 1,261 ± 359 ms vs. 933 ± 104 ms, p = 0.0008; T2: 65 ± 51 ms vs. 38 ± 8 ms, p = 0.008), as well as from tumor (T1: 1,261 ± 371 ms vs. 1,462 ± 248 ms, p = 0.047).
conclusionsMRF is a fast sequence that can rapidly distinguish important tissue components in pediatric brain tumor patients. MRF-derived T1 and T2 distinguished tumor from normal-appearing white matter, differentiated tumor grade, and found abnormalities in peritumoral regions. MRF may be useful for rapid quantitative measurement of tissue characteristics and distinguish tumor grade in children and young adults with brain tumors.
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