Evidence map›Paper›PMID 31415865›Full record

ArticleNeuroscience and biobehavioral reviews2019

Variation in brain structure volumes in schizophrenia: A commentary.

Luca De Peri, Antonio Vita

Abstract readComment
PubMed Publisher
In one paragraph

Article in Neuroscience and biobehavioral reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Luca De PeriCantonal Psychiatric Clinic, Cantonal Socio-Psychiatric Association, Mendrisio, Switzerland. Electronic address: luca.deperi@ti.ch.
Antonio VitaUniversity of Brescia School of Medicine, Department of Mental Health, Spedali Civili Hospital, Brescia, Italy. Electronic address: antonio.vita@unibs.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, Kuo and Pogue-Geile (2019) quantitatively reviewed Magnetic Resonance Imaging (MRI) findings in patients with schizophrenia demonstrating, besides altered volume of several brain structures significantly greater structural variability in patients relative to controls as for intracranial, lateral and third ventricles volumes. We believe that additional points could be usefully included in the discussion of the conceptual meaning of these findings. In this commentary, first we highlight the role of potential confounding factors such as antipsychotic medication intake and duration of illness when interpreting MRI data in schizophrenia. Second, we discuss the finding of greater variability of cerebral structure volumes in the broader context of the pathophysiology and time course of brain abnormalities in the disease.

Indexed as

Antipsychotic AgentsBrain DiseasesSchizophreniaBrainHumansMagnetic Resonance ImagingAntipsychotic AgentsAntipsychoticsBrain volume changesBrain volumes variabilityMagnetic resonance imagingMeta-analysisSchizophrenia

Identifiers

PMID31415865

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.