The Gut Feeling: GPCRs Enlighten the Way.

Shubhi Pandey, Jagannath Maharana, Arun K Shukla

Open access · bronzeAbstract readComment

In one paragraph

Article in Cell host & microbe, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it

0cells of the map it votes in

4citing papers in PubMed

0.4field-weighted citation impact, top 38% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

Precision Psychobiotics for Gut-Brain Axis Health: Advancing the Discovery Pipelines to Deliver Mechanistic Pathways and Proven Health Efficacy.Microbial biotechnology · 2025
Review
Systematic characterization of multi-omics landscape between gut microbial metabolites and GPCRome in Alzheimer's disease.Cell reports · 2024
Article
Potential for host-symbiont communication via neurotransmitters and neuromodulators in an aneural animal, the marine spongeFrontiers in neural circuits · 2023
Article
Key features of the genetic architecture and evolution of host-microbe interactions revealed by high-resolution genetic mapping of the mucosa-associated gut microbiome in hybrid mice.eLife · 2022
Article

4 · The record

Corrections and comments

Comment on
Commensal bacteria make GPCR ligands that mimic human signalling molecules.2017
Comment on
Mapping Interactions of Microbial Metabolites with Human G-Protein-Coupled Receptors.2019

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Shubhi PandeyDepartment of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur 208016, India.

Jagannath MaharanaDepartment of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur 208016, India.

Arun K ShuklaDepartment of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur 208016, India. Electronic address: arshukla@iitk.ac.in.

Indian Institute of Technology Kanpur · IN

Funding

DBT-Wellcome Trust India Alliance IA/I/14/1/501285Wellcome Trust

6 · The paper itself

Abstract

Host-microbiome interactions affect host physiology, but the underlying mechanisms are not well understood. Recent papers from Chen et al. (2019) and Colosimo et al. (2019) in this issue of Cell Host & Microbe demonstrate that metabolites produced by several members of the gut microbiota can efficiently activate host G protein-coupled receptors and influence host physiology.

Indexed as

MicrobiotaReceptors, G-Protein-CoupledBacteriaHumansLigandsSignal TransductionLigandsReceptors, G-Protein-Coupled

Identifiers

PMID31415748

DOI10.1016/j.chom.2019.07.018

PMCPMC7115877

OpenAlexW2967735220

What OpenQuestion holds

Textmetadata

LicenceTDM

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.