ArticlePLoS genetics2019
Genetic screens reveal novel major and minor players in magnesium homeostasis of Staphylococcus aureus.
Article in PLoS genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- CorAVeterinary research · 2026Article
- Strain matters: host responses reflect symbiont origin in the squid-vibrio symbiosis.mSystems · 2025Article
- Magnesium modulates the stress responses of oral streptococci to environmental and antibiotic challenges by altering cell envelope and nutrient transport pathways.Frontiers in microbiology · 2025Article
- Bioinformatic prediction of proteins relevant to functions of the bacterial OLE ribonucleoprotein complex.mSphere · 2024Article
- The genesApplied and environmental microbiology · 2024Article
- Experimental evolution ofmBio · 2024Article
- Understanding the Effect of Different Glucose Concentrations in the Oligotrophic BacteriumMicroorganisms · 2023Article
- A tonoplast-localized magnesium transporter is crucial for stomatal opening in Arabidopsis under high MgThe New phytologist · 2022Article
- The type IX secretion system: Insights into its function and connection to glycosylation inEngineering microbiology · 2022Review
- Article
- Transmission and microevolution of methicillin-resistantFrontiers in public health · 2022Article
- Crystal structure of an archaeal CorB magnesium transporter.Nature communications · 2021Article
- Article
- Structural basis for the MgScience advances · 2021Article
- The (p)ppGpp Synthetase RSH Mediates Stationary-Phase Onset and Antibiotic Stress Survival in Clostridioides difficile.Journal of bacteriology · 2020Article
- Article
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Authors and funding
4 authors.
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Abstract
Magnesium is one of the most abundant metal ions in living cells. Very specific and devoted transporters have evolved for transporting Mg2+ ions across the membrane and maintain magnesium homeostasis. Using genetic screens, we were able to identify the main players in magnesium homeostasis in the opportunistic pathogen Staphylococcus aureus. Here, we show that import of magnesium relies on the redundant activity of either CorA2 or MgtE since in absence of these two importers, bacteria require increased amounts of magnesium in the medium. A third CorA-like importer seems to play a minor role, at least under laboratory conditions. For export of magnesium, we identified two proteins, MpfA and MpfB. MpfA, is the main actor since it is essential for growth in high magnesium concentrations. We show that gain of function mutations or overexpression of the minor factor, MpfB, which is part of a sigmaB controlled stress response regulon, can compensate for the absence of MpfA.
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