ArticlePLoS biology2019
Coordinated circadian timing through the integration of local inputs in Arabidopsis thaliana.
Article in PLoS biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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Who cites it
26 citing papers in PubMed, 48 citations in OpenAlex.
- Thermal imaging as a tool for studying circadian rhythms in roots.The Plant journal : for cell and molecular biology · 2026Article
- A PROMOTER::LUCIFERASE reporter system reveals key elements of the circadian regulation of Crassulacean acid metabolism (CAM) in Kalanchoë laxiflora Baker.The Plant journal : for cell and molecular biology · 2026Article
- Time after time: a quarter century of progress in plant circadian biology.Npj biological timing and sleep · 2026Review
- Review
- An Arabidopsis Cell Culture With Weak Circadian Rhythms Under Constant Light Compared With Constant Dark Can Be Rescued by ELF3.Plant direct · 2024Article
- Decoding the plant clock: a review of mathematical models for the circadian regulatory network.Plant molecular biology · 2024Review
- Dissecting the complexity of local and systemic circadian communication in plants.Npj biological timing and sleep · 2024Review
- Root PRR7 Improves the Accuracy of the Shoot Circadian Clock through Nutrient Transport.Plant & cell physiology · 2023Article
- Spatially specific mechanisms and functions of the plant circadian clock.Plant physiology · 2022Review
- Keeping time in the dark: Potato diel and circadian rhythmic gene expression reveals tissue-specific circadian clocks.Plant direct · 2022Article
- A spatial model of the plant circadian clock reveals design principles for coordinated timing.Molecular systems biology · 2022Article
- A crosstalk of circadian clock and alternative splicing under abiotic stresses in the plants.Frontiers in plant science · 2022Review
- High Spatial Resolution Luciferase Imaging of the Arabidopsis thaliana Circadian Clock.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Review
- The Cell Division Cycle ofPlants (Basel, Switzerland) · 2021Article
- Review
- Review
- The singularity response reveals entrainment properties of the plant circadian clock.Nature communications · 2021Article
- XAP5 CIRCADIAN TIMEKEEPER Affects Both DNA Damage Responses and Immune Signaling inFrontiers in plant science · 2021Article
- Overcoming the Challenges to Enhancing Experimental Plant Biology With Computational Modeling.Frontiers in plant science · 2021Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Individual plant cells have a genetic circuit, the circadian clock, that times key processes to the day-night cycle. These clocks are aligned to the day-night cycle by multiple environmental signals that vary across the plant. How does the plant integrate clock rhythms, both within and between organs, to ensure coordinated timing? To address this question, we examined the clock at the sub-tissue level across Arabidopsis thaliana seedlings under multiple environmental conditions and genetic backgrounds. Our results show that the clock runs at different speeds (periods) in each organ, which causes the clock to peak at different times across the plant in both constant environmental conditions and light-dark (LD) cycles. Closer examination reveals that spatial waves of clock gene expression propagate both within and between organs. Using a combination of modeling and experiment, we reveal that these spatial waves are the result of the period differences between organs and local coupling, rather than long-distance signaling. With further experiments we show that the endogenous period differences, and thus the spatial waves, can be generated by the organ specificity of inputs into the clock. We demonstrate this by modulating periods using light and metabolic signals, as well as with genetic perturbations. Our results reveal that plant clocks can be set locally by organ-specific inputs but coordinated globally via spatial waves of clock gene expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.