SynthesisRadiation research2019
Meta-analysis of Cognitive Performance by Novel Object Recognition after Proton and Heavy Ion Exposures.
Synthesis in Radiation research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed.
- Using Organoids to Unlock the Potential of Human Torpor for Spaceflight.Current stem cell reports · 2026Article
- Galactic cosmic radiation produces sex-specific, circuit-selective cognitive vulnerability: countermeasure trade-offs revealed by multi-domain assessment.Research square · 2026Article
- The longitudinal behavioral effects of acute exposure to galactic cosmic radiation in female C57BL/6J mice: Implications for deep space missions, female crews, and potential antioxidant countermeasures.Journal of neurochemistry · 2025Article
- Short-term microgravity effects simulation does not affect fNIRS measures of cerebral oxygenation changes induced by cognitive load.Frontiers in physiology · 2025Article
- A competing risks machine learning study of neutron dose, fractionation, age, and sex effects on mortality in 21,000 mice.Scientific reports · 2024Article
- Neuropsychological considerations for long-duration deep spaceflight.Frontiers in physiology · 2023Review
- Nano-scale simulation of neuronal damage by galactic cosmic rays.Physics in medicine and biology · 2022Article
- Cranial irradiation impairs intrinsic excitability and synaptic plasticity of hippocampal CA1 pyramidal neurons with implications for cognitive function.Neural regeneration research · 2022Article
- A practical approach for continuous in situ characterization of radiation quality factors in space.Scientific reports · 2022Article
- An estimate assay for low-level exposure to ionizing radiation based on mass spectrometry quantification of γ-H2AX in human peripheral blood lymphocytes.Frontiers in public health · 2022Article
- The Burden of Space Exploration on the Mental Health of Astronauts: A Narrative Review.Clinical neuropsychiatry · 2021Review
- Modeling space radiation induced cognitive dysfunction using targeted and non-targeted effects.Scientific reports · 2021Article
- Life-long brain compensatory responses to galactic cosmic radiation exposure.Scientific reports · 2021Article
- Dose-Effects Models for Space Radiobiology: An Overview on Dose-Effect Relationships.Frontiers in public health · 2021Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Experimental studies of cognitive detriments in mice and rats after proton and heavy ion exposures have been performed by several laboratories to investigate possible risks to astronauts exposed to cosmic rays in space travel and patients treated for brain cancers with proton and carbon beams in Hadron therapy. However, distinct radiation types and doses, cognitive tests and rodent models have been used by different laboratories, while few studies have considered detailed dose-response characterizations, including estimates of relative biological effectiveness (RBE). Here we report on the first quantitative meta-analysis of the dose response for proton and heavy ion rodent studies of the widely used novel object recognition (NOR) test, which estimates detriments in recognition or object memory. Our study reveals that linear or linear-quadratic dose-response models of relative risk (RR) do not provide accurate descriptions. However, good descriptions for doses up to 1 Gy are provided by exponentially increasing fluence or dose-response models observed with an LET dependence similar to a classical radiation quality response, which peaks near 100-120 keV/µm and declines at higher LET values. Exponential models provide accurate predictions of experimental results for NOR in mice after mixed-beam exposures of protons and
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.