ArticleAnalytical chemistry2019
Ultrasensitive Detection of Human Chorionic Gonadotropin Using Frequency Locked Microtoroid Optical Resonators.
Article in Analytical chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 50 citations in OpenAlex.
- Liquid photonic-molecule microlasers for ultrasensitive biosensing.Nature communications · 2026Article
- Accelerating GPCR drug discovery through computation and experiment integrated with direct detection of ligand binding events.npj drug discovery · 2026Review
- FLOWER: a frequency-locked optical whispering evanescent resonator for label-free molecular detection.Chemical communications (Cambridge, England) · 2025Review
- Unveiling local molecular desorption dynamics using higher-order optical resonances.Frontiers of optoelectronics · 2025Article
- Frequency locked whispering evanescent resonator (FLOWER) for biochemical sensing applications.Nature protocols · 2025Review
- High Quality-Factor All-Dielectric Metacavity for Label-Free Biosensing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Optical biosensors for diagnosing neurodegenerative diseases.Npj biosensing · 2025Review
- Steviol rebaudiosides bind to four different sites of the human sweet taste receptor (T1R2/T1R3) complex explaining confusing experiments.Communications chemistry · 2024Article
- Microfluidics and Nanofluidics in Strong Light-Matter Coupling Systems.Nanomaterials (Basel, Switzerland) · 2024Review
- Label-free, real-time monitoring of membrane binding events at zeptomolar concentrations using frequency-locked optical microresonators.Nature communications · 2024Article
- Single 5-nm quantum dot detection via microtoroid optical resonator photothermal microscopy.Light, science & applications · 2024Article
- High-Q WGM microcavity-based optofluidic sensor technologies for biological analysis.Biomicrofluidics · 2024Review
- Methotrexate Inhibits the Binding of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Receptor Binding Domain to the Host-Cell Angiotensin-Converting Enzyme-2 (ACE-2) Receptor.ACS pharmacology & translational science · 2024Article
- Towards early diagnosis and screening of Alzheimer's disease using frequency locked whispering gallery mode microtoroids.Npj biosensing · 2024Article
- Label-free, real-time monitoring of membrane binding events at zeptomolar concentrations using frequency-locked optical microresonators.bioRxiv : the preprint server for biology · 2023Article
- An Integrated Approach to Protein Discovery and Detection From Complex Biofluids.Molecular & cellular proteomics : MCP · 2023Article
- Impact of stimulated Raman scattering on dark soliton generation in a silica microresonator.JPhys photonics · 2023Article
- Optical frequency combs in aqueous and air environments at visible to near-IR wavelengths.Optics express · 2022Article
- Nanogold/graphene as sensing platform coupled with ferrocene/gold as signal amplifier for sandwich-like voltammetric immunosensor of human chorionic gonadotropin.American journal of translational research · 2022Article
- Photonic technologies for liquid biopsies: recent advances and open research challenges.Laser & photonics reviews · 2021Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Clean sport competition is of significant concern to many governments and sporting organizations. Highly sensitive and rapid sensors are needed to improve the detection of performance enhancing drugs in sports as athletes take diuretics to dilute the concentration of drugs in their urine and microdose under the detectable limits of current sensors. Here we demonstrate, using frequency locked microtoroid optical resonators, a 3 orders of magnitude improvement in detection limit over the current gold standard, mass spectrometry, for the common performance enhancing drug, human chorionic gonadotropin (hCG). hCG, also known as the pregnancy hormone, was detected both in simulated urine and in the urine of pregnant donors at a concentration of 1 and 3 femtomolar, respectively. We anticipate that the sensitivity provided by frequency locked optical microcavities can enable a new standard in antidoping research.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.