ArticleThe Journal of clinical endocrinology and metabolism2019
Factors Associated With Diagnosis and Treatment of Thyroid Microcarcinomas.
Article in The Journal of clinical endocrinology and metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Prevalence of Subclinical Papillary Thyroid Cancer by Age: Meta-analysis of Autopsy Studies.The Journal of clinical endocrinology and metabolism · 2022Pooled it
- Pooled it
- Unravelling the rise in thyroid cancer incidence and addressing overdiagnosis.Nature reviews. Endocrinology · 2026Review
- Multifocal papillary thyroid microcarcinomas: is the total tumor diameter associated with the tumor behavior? A retrospective cohort study.Einstein (Sao Paulo, Brazil) · 2025Article
- Article
- Rates of Detecting Thyroid Nodules Recommended for Biopsy with Ultrasound: Are All Indications Equal?Thyroid : official journal of the American Thyroid Association · 2023Observational
- Drivers of Thyroid Ultrasound Use: A Retrospective Observational Study.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2023Observational
- Change in worry over time among Hispanic women with thyroid cancer.Journal of cancer survivorship : research and practice · 2022Article
- Physician Specialties Involved in Thyroid Cancer Diagnosis and Treatment: Implications for Improving Health Care Disparities.The Journal of clinical endocrinology and metabolism · 2022Article
- Financial Hardship Among Hispanic Women with Thyroid Cancer.Thyroid : official journal of the American Thyroid Association · 2021Article
- Thyroid Nodule Evaluation and Management in Older Adults: A Review of Practical Considerations for Clinical Endocrinologists.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2021Review
- S100A1 is a Potential Biomarker for Papillary Thyroid Carcinoma Diagnosis and Prognosis.Journal of Cancer · 2021Article
- Physician-Reported Misuse of Thyroid Ultrasonography.JAMA surgery · 2020Article
- Cancer incidence and mortality following treatment of hyperthyroidism with radioactive iodine.Current opinion in endocrinology, diabetes, and obesity · 2020Review
- Disparities Research in Thyroid Cancer: Challenges and Strategies for Improvement.Thyroid : official journal of the American Thyroid Association · 2020Article
- The Relationship Between Imaging and Thyroid Cancer Diagnosis and Survival.The oncologist · 2020Article
- Too Much of a Good Thing? A Cautionary Tale of Thyroid Cancer Overdiagnosis and Overtreatment.Thyroid : official journal of the American Thyroid Association · 2020Article
- Early Diagnosis of Low-Risk Papillary Thyroid Cancer Results Rather in Overtreatment Than a Better Survival.Frontiers in endocrinology · 2020Review
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6 authors at 3 institutions in 1 country.
Funding
Abstract
contextNearly one-third of all thyroid cancers are ≤1 cm.
objectiveTo determine diagnostic pathways for microcarcinomas vs larger cancers. DESIGN/SETTING/
participantsPatients from Georgia and Los Angeles Surveillance, Epidemiology, and End Results (SEER) registries with differentiated thyroid cancer diagnosed in 2014 or 2015 were surveyed. Survey data were linked to SEER data on tumor and treatment characteristics. Multivariable logistic regression analysis was performed.
main outcome measuresMethod of nodule discovery; reason for thyroid surgery.
resultsOf patients who underwent surgery, 975 (38.2%) had cancers ≤1 cm, and 1588 cancers (61.8%) were >1 cm. The reported method of nodule discovery differed significantly between patients with cancers ≤1 cm and those with cancers >1 cm (P < 0.001). Cancer ≤1 cm was associated with nodule discovery on thyroid ultrasound (compared with other imaging, OR, 1.59; 95% CI, 1.21 to 2.10), older patient age (45 to 54 years vs ≤44, OR, 1.45; 95% CI, 1.16 to 1.82), and female sex (OR, 1.51; 95% CI, 1.22 to 1.87). Hispanic ethnicity (OR, 0.71; 95% CI, 0.57 to 0.89) and Asian race (OR, 0.67; 95% CI, 0.49 to 0.92) were negative correlates. Cancers ≤1 cm were associated with lower likelihood of surgery for a nodule suspicious or consistent with cancer (OR, 0.48; 95% CI, 0.40 to 0.57).
conclusionThyroid microcarcinomas are more likely to be detected by ultrasound and less likely to be associated with surgery scheduled for known thyroid cancer. Understanding diagnostic pathways allows for targeted interventions to decrease overdiagnosis and overtreatment.
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