Evidence map›Paper›PMID 31414986›Full record

ArticleeLife2019

Repression of ferritin light chain translation by human eIF3.

Mia C Pulos-Holmes, Daniel N Srole, Maria G Juarez, Amy S-Y Lee, David T McSwiggen, Nicholas T Ingolia, Jamie H Cate

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
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  5. Article
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  7. Article
  8. bioRxiv : the preprint server for biology · 2023
    Article
  9. Article
  10. A highly efficient human cell-free translation system.bioRxiv : the preprint server for biology · 2023
    Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Mia C Pulos-HolmesDepartment of Molecular & Cell Biology, University of California, Berkeley, Berkeley, United States.ORCID 0000-0002-8234-4020
Daniel N SroleDepartment of Molecular & Cell Biology, University of California, Berkeley, Berkeley, United States.
Maria G JuarezDepartment of Molecular & Cell Biology, University of California, Berkeley, Berkeley, United States.
Amy S-Y LeeBiology Department, Rosenstiel Basic Medical Science Research Center, Brandeis University, Waltham, United States.
David T McSwiggenDepartment of Molecular & Cell Biology, University of California, Berkeley, Berkeley, United States.ORCID 0000-0003-3844-7433
Nicholas T IngoliaDepartment of Molecular & Cell Biology, University of California, Berkeley, Berkeley, United States.ORCID 0000-0002-3395-1545
Jamie H CateDepartment of Molecular & Cell Biology, University of California, Berkeley, Berkeley, United States.ORCID 0000-0001-5965-7902
University of California, Berkeley · USQB3 · USBrandeis University · US

Funding

PROJECT 3P50GM102706 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI CATE, JAMIE H · 2012 to 2016
$9.5M
The Role of the Ribosome in the Accuracy of TranslationR01GM065050 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI CATE, JAMIE H · 2001 to 2022
$7.4M
American Heart Association 16PRE30140013NIGMS NIH HHS P50 GM102706NIGMS NIH HHS R01 GM065050
6 · The paper itself

Abstract

A central problem in human biology remains the discovery of causal molecular links between mutations identified in genome-wide association studies (GWAS) and their corresponding disease traits. This challenge is magnified for variants residing in non-coding regions of the genome. Single-nucleotide polymorphisms (SNPs) in the 5' untranslated region (5'-UTR) of the ferritin light chain (

Indexed as

Down-RegulationProtein Biosynthesis5' Untranslated RegionsApoferritinsCell LineEukaryotic Initiation Factor-3HumansPolymorphism, Single Nucleotide5' Untranslated RegionsApoferritinsEukaryotic Initiation Factor-3biochemistrychemical biologyeIF3ferritin light chainhumanhuman biologyiron homeostasisiron response proteinmedicinetranslation regulation

Identifiers

PMID31414986
PMCPMC6721798
OpenAlexW2967931898

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.