Evidence map›Paper›PMID 31414920›Full record

ReviewExpert opinion on therapeutic targets2019

Macrophage migration inhibitory factor (MIF) as a therapeutic target for rheumatoid arthritis and systemic lupus erythematosus.

Joshua B Bilsborrow, Edward Doherty, Pathricia V Tilstam, Richard Bucala

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Expert opinion on therapeutic targets, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04315818 (The Relation Between Macrophage Migration Inhibitory Factor), which is not on this map. Cited by 92 papers.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04315818 unknown statusnot on this mapstarted 2021, after this paper: background citation

The Relation Between Macrophage Migration Inhibitory Factor (MIF) and 25(OH) Vitamin D3 Serum Levels in Rheumatoid Arthritis

TypeobservationalSponsorAssiut UniversityRan2021 to 2023Enrolled70ConditionsRheumatoid Arthritis
3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 164 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Methods to Determine the Role of MIF in Cilia Biogenesis.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Galectin-9 inhibition of the MIF-CD74/CD44 pathway suppresses chronic arthritis.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
  15. Article
  16. Observational
  17. Review
  18. Article
  19. Review
  20. Article

32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Joshua B BilsborrowDepartment of Internal Medicine, Yale University School of Medicine , New Haven , CT , USA.ORCID 0000-0002-1432-0596
Edward DohertyDepartment of Internal Medicine, Yale University School of Medicine , New Haven , CT , USA.
Pathricia V TilstamDepartment of Internal Medicine, Yale University School of Medicine , New Haven , CT , USA.
Richard BucalaDepartment of Internal Medicine, Yale University School of Medicine , New Haven , CT , USA.
Yale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
TRAINING PROGRAM IN INVESTIGATIVE RHEUMATOLOGYT32AR007107 · NIAMS · YALE UNIVERSITY · PI RICHARD J BUCALA · 1986 to 2026
$7.5M
Mechanisms of Rheumatoid Synovial Fibroblast ActivationR01AR049610 · NIAMS · YALE UNIVERSITY · PI BUCALA, RICHARD J · 2002 to 2018
$5.0M
NCATS NIH HHS UL1 TR001863NIAMS NIH HHS R01 AR049610NIAMS NIH HHS T32 AR007107
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsArthritis, RheumatoidHumansIntramolecular OxidoreductasesLupus Erythematosus, SystemicMacrophage Migration-Inhibitory FactorsMicePolymorphism, GeneticPrecision MedicineIntramolecular OxidoreductasesMacrophage Migration-Inhibitory FactorsMIF protein, humanCD44CD74CXCR2CXCR4CXCR7D-DT/MIF-2macrophage migration inhibitory factor (MIF)precision medicine

Identifiers

PMID31414920
PMCPMC6800059
OpenAlexW2967597008

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.