Evidence map›Paper›PMID 31414826›Full record

ArticleOrganic letters2019

Discovery and Total Synthesis of Doscadenamide A: A Quorum Sensing Signaling Molecule from a Marine Cyanobacterium.

Xiao Liang, Susan Matthew, Qi-Yin Chen, Jason C Kwan, Valerie J Paul, Hendrik Luesch

Open access · greenAbstract read
In one paragraph

Article in Organic letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Xiao LiangDepartment of Medicinal Chemistry , University of Florida , Gainesville , Florida 32610 , United States.
Susan MatthewDepartment of Medicinal Chemistry , University of Florida , Gainesville , Florida 32610 , United States.
Qi-Yin ChenDepartment of Medicinal Chemistry , University of Florida , Gainesville , Florida 32610 , United States.
Jason C KwanDepartment of Medicinal Chemistry , University of Florida , Gainesville , Florida 32610 , United States.
Valerie J PaulSmithsonian Marine Station , Fort Pierce , Florida 34949 , United States.ORCID 0000-0002-4691-1569
Hendrik LueschDepartment of Medicinal Chemistry , University of Florida , Gainesville , Florida 32610 , United States.ORCID 0000-0002-4091-7492
University of Florida · USSmithsonian Marine Station · US

Funding

Novel Targeted Anticancer Agents from Marine CyanobacteriaR01CA172310 · NCI · UNIVERSITY OF FLORIDA · PI HENDRIK LUESCH · 2013 to 2026
$5.8M
Pilot-Scale Libraries of Marine Cyanobacterial Natural ProductsP41GM086210 · NIGMS · UNIVERSITY OF FLORIDA · PI LUESCH, HENDRIK, PAUL, VALERIE JEAN · 2008 to 2010
$1.2M
NCI NIH HHS R01 CA172310NIGMS NIH HHS P41 GM086210
6 · The paper itself

Abstract

Quorum sensing (QS) plays a critical role in the regulation of bacterial pathogenesis. Doscadenamide A (

Indexed as

Drug DiscoveryAnti-Bacterial AgentsCyanobacteriaMicrobial Sensitivity TestsMolecular StructurePseudomonas aeruginosaPyrrolesQuorum SensingSignal TransductionAnti-Bacterial Agentsdoscadenamide APyrroles

Identifiers

PMID31414826
PMCPMC7325281
OpenAlexW2969141483

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.