Evidence map›Paper›PMID 31414515›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2019

Surfactant-Stripped Micelles for NIR-II Photoacoustic Imaging through 12 cm of Breast Tissue and Whole Human Breasts.

Upendra Chitgupi, Nikhila Nyayapathi, Jeesu Kim, Depeng Wang, Boyang Sun, Changning Li, Kevin Carter, Wei-Chiao Huang, Chulhong Kim, Jun Xia and 1 more

Open access · greenAbstract read
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 117 citations in OpenAlex.

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  7. Bornite (CuPhotoacoustics · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Upendra ChitgupiDepartment of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, NY, 14260, USA.
Nikhila NyayapathiDepartment of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, NY, 14260, USA.
Jeesu KimDepartments of Creative IT Engineering, Mechanical Engineering and Electrical Engineering, Pohang University of Science and Technology (POSTECH), Pohang, Gyeongbuk, 37673, Republic of Korea.
Depeng WangDepartment of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, NY, 14260, USA.
Boyang SunDepartment of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY, 14260, USA.
Changning LiDepartment of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, NY, 14260, USA.
Kevin CarterDepartment of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, NY, 14260, USA.
Wei-Chiao HuangDepartment of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, NY, 14260, USA.
Chulhong KimDepartments of Creative IT Engineering, Mechanical Engineering and Electrical Engineering, Pohang University of Science and Technology (POSTECH), Pohang, Gyeongbuk, 37673, Republic of Korea.
Jun XiaDepartment of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, NY, 14260, USA.
Jonathan F LovellDepartment of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, NY, 14260, USA.ORCID https://orcid.org/0000-0002-9052-884X
University at Buffalo, State University of New York · USPohang University of Science and Technology · KR

Funding

Light-Triggered Drug Release in Primed Pancreatic TumorsR01EB017270 · NIBIB · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI LOVELL, JONATHAN F · 2013 to 2021
$3.5M
Targeting Tumors with Resealable Nanovesicles Permeabilized by NIR LightDP5OD017898 · OD · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI LOVELL, JONATHAN F · 2013 to 2017
$1.9M
National Research Foundation of Korea NRF-2019R1A2C2006269National Science Foundation 1555220NIBIB NIH HHS R01 EB017270NIH HHS DP5 OD017898NIH HHS DP5OD017898NIH HHS R01EB017270Susan G. Komen Foundation CCR17481211University at Buffalo Clinical and Translational Science Institute
6 · The paper itself

Abstract

Surfactant-stripped micelles are formed from a commercially available cyanine fluoroalkylphosphate (CyFaP) salt dye and used for high contrast photoacoustic imaging (PAI) in the second near-infrared window (NIR-II). The co-loading of Coenzyme Q10 into surfactant-stripped CyFaP (ss-CyFaP) micelles improves yield, storage stability, and results in a peak absorption wavelength in the NIR-II window close to the 1064 nm output of Nd-YAG lasers used for PAI. Aqueous ss-CyFaP dispersions exhibit intense NIR-II optical absorption, calculated to be greater than 500 at 1064 nm. ss-CyFaP is detected through 12 cm of chicken breast tissue with PAI. In preclinical animal models, ss-CyFaP is visualized in draining lymph nodes of rats through 3.1 cm of overlaid chicken breast tissue. Following intravenous administration, ss-CyFaP accumulates in neoplastic tissues of mice and rats bearing orthotopic mammary tumors without observation of acute toxic side effects. ss-CyFaP is imaged through whole compressed human breasts in three female volunteers at depths of 2.6-5.1 cm. Taken together, these data show that ss-CyFaP is an accessible contrast agent for deep tissue PAI in the NIR-II window.

Indexed as

Infrared RaysMicellesAbsorption, PhysicochemicalAnimalsBreastHumansMiceOptical ImagingPhosphatesPhotoacoustic TechniquesRatsSurface-Active AgentsUbiquinonecoenzyme Q10MicellesPhosphatesSurface-Active AgentsUbiquinonecyaninemicellesphotoacoustic imagingPluronic

Identifiers

PMID31414515
PMCPMC6773519
OpenAlexW2968521490

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.