ArticleRapid communications in mass spectrometry : RCM2019
Paper spray screening and liquid chromatography/mass spectrometry confirmation for medication adherence testing: A two-step process.
Article in Rapid communications in mass spectrometry : RCM, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Analysis of Drugs in Whole Blood by Paper Spray Mass Spectrometry with Integrated Solid-Phase Extraction.Analytical chemistry · 2025Article
- Performance Comparison of Ambient Ionization Techniques Using a Single Quadrupole Mass Spectrometer for the Analysis of Amino Acids, Drugs, and Explosives.Journal of the American Society for Mass Spectrometry · 2024Article
- Therapeutic drug monitoring of clozapine in human serum by high-throughput paper spray mass spectrometry.Journal of mass spectrometry and advances in the clinical lab · 2024Article
- Determination of carbamazepine in fingerprints: a feasibility study to evaluate adherence in epilepsy patients.Bioanalysis · 2024Article
- Noninvasive drug adherence monitoring of antipsychotic patients via finger sweat testing.Frontiers in chemistry · 2023Article
- Potential to Use Fingerprints for Monitoring Therapeutic Levels of Isoniazid and Treatment Adherence.ACS omega · 2022Article
- Paper spray screening and liquid chromatography/mass spectrometry confirmation for medication adherence testing: A two-step process.Rapid communications in mass spectrometry : RCM · 2019Article
- Exploring a route to a selective and sensitive portable system for explosive detection- swab spray ionisation coupled to of high-field assisted waveform ion mobility spectrometry (FAIMS).Forensic science international. Synergy · 2019Article
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Authors and funding
8 authors.
Funding
Abstract
rationalePaper spray offers a rapid screening test without the need for sample preparation. The incomplete extraction of paper spray allows for further testing using more robust, selective and sensitive techniques such as liquid chromatography/mass spectrometry (LC/MS). Here we develop a two-step process of paper spray followed by LC/MS to (1) rapidly screen a large number of samples and (2) confirm any disputed results. This demonstrates the applicability for testing medication adherence from a fingerprint.
methodsFollowing paper spray analysis, drugs of abuse samples were analysed using LC/MS. All analyses were completed using a Q Exactive™ Plus Orbitrap™ mass spectrometer. This two-step procedure was applied to fingerprints collected from patients on a maintained dose of the antipsychotic drug quetiapine.
resultsThe extraction efficiency of paper spray for two drugs of abuse and metabolites was found to be between 15 and 35% (analyte dependent). For short acquisition times, the extraction efficiency was found to vary between replicates by less than 30%, enabling subsequent analysis by LC/MS. This two-step process was then applied to fingerprints collected from two patients taking the antipsychotic drug quetiapine, which demonstrates how a negative screening result from paper spray can be resolved using LC/MS.
conclusionsWe have shown for the first time the sequential analysis of the same sample using paper spray and LC/MS, as well as the detection of an antipsychotic drug from a fingerprint. We propose that this workflow may also be applied to any type of sample compatible with paper spray, and will be especially convenient where only one sample is available for analysis.
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Registered trials
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