Evidence map›Paper›PMID 31414384›Full record

ArticleNeuromolecular medicine2020

C1 Esterase Inhibitor Reduces BBB Leakage and Apoptosis in the Hypoxic Developing Mouse Brain.

Susan Jung, Hans-Georg Topf, Gudrun Boie, Regina Trollmann

Abstract read
PubMed Publisher
In one paragraph

Article in Neuromolecular medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Susan JungDivision of Neuropediatrics, Department of Pediatrics, Friedrich-Alexander University Erlangen-Nürnberg, Loschgestr. 15, 91054, Erlangen, Germany.
Hans-Georg TopfDivision of Neonatology, Department of Pediatrics, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
Gudrun BoieDivision of Neuropediatrics, Department of Pediatrics, Friedrich-Alexander University Erlangen-Nürnberg, Loschgestr. 15, 91054, Erlangen, Germany.
Regina TrollmannDivision of Neuropediatrics, Department of Pediatrics, Friedrich-Alexander University Erlangen-Nürnberg, Loschgestr. 15, 91054, Erlangen, Germany. regina.trollmann@uk-erlangen.de.
Friedrich-Alexander-Universität Erlangen-Nürnberg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammatory pathways involved in blood-brain barrier (BBB) vulnerability and hypoxic brain oedema in models of perinatal brain injury seem to provide putative therapeutic targets. To investigate impacts of C1-esterase inhibitor (C1-INH; 7.5-30 IU/kg, i.p.) on functional BBB properties in the hypoxic developing mouse brain (P7; 8% O

Indexed as

AnimalsAnimals, NewbornApoptosisBlood-Brain BarrierBrainComplement C1 Inhibitor ProteinDisease Models, AnimalDual Specificity Phosphatase 1FemaleGene Expression Regulation, DevelopmentalHypoxiaHypoxia, BrainInflammation MediatorsMembrane ProteinsMiceMice, Inbred C57BLBNip3 protein, mouseComplement C1 Inhibitor ProteinDual Specificity Phosphatase 1Dusp1 protein, mouseInflammation MediatorsMembrane ProteinsMitochondrial ProteinsNerve Tissue ProteinsOccludinOcln protein, mouseRNA, MessengerS100b protein, mouseS100 Calcium Binding Protein beta SubunitTight Junction ProteinsBNIP3DUSP1HypoxiaMatrix metalloproteinasesNeonatal brain injuryNeuroprotectionOccludinS100b proteinTight junctions

Identifiers

PMID31414384
OpenAlexW2968721794

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.