ReviewPharmaceutical research2019
Medications in Space: In Search of a Pharmacologist's Guide to the Galaxy.
Review in Pharmaceutical research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Anticoagulants for the prevention and treatment of venous thromboembolism in humans exposed to microgravity: A hybrid systematic and narrative review.American heart journal plus : cardiology research and practice · 2026Review
- Feasibility of dried blood spot collection for caffeine pharmacokinetic studies in microgravity: Insights from parabolic flight campaigns.British journal of clinical pharmacology · 2026Article
- Advanced Pharmaceutical Science and Technology in Israel.Pharmaceutics · 2025Article
- Repetitive stability study of remdesivir/cyclodextrin complex on the international space station.Scientific reports · 2025Article
- Pharmacological Innovations in Space: Challenges and Future Perspectives.Pharmaceutical research · 2024Review
- Differential Effect of Simulated Microgravity on the Cellular Uptake of Small Molecules.Pharmaceutics · 2024Article
- Genetic diversity, clinical uses, and phytochemical and pharmacological properties of safflower (Frontiers in pharmacology · 2024Review
- Simulated Microgravity-Induced Changes to Drug Response in Cancer Cells Quantified Using Fluorescence Morphometry.Life (Basel, Switzerland) · 2023Article
- Simulated Microgravity Alters P-Glycoprotein Efflux Function and Expression via the Wnt/β-Catenin Signaling Pathway in Rat Intestine and Brain.International journal of molecular sciences · 2023Article
- D-Mannose prevents bone loss under weightlessness.Journal of translational medicine · 2023Article
- Training and Education Requirements for Pharmacists in Zero Gravity Environments.Innovations in pharmacy · 2023Article
- Small tissue chips with big opportunities for space medicine.Life sciences in space research · 2022Article
- Physiological adaptations affecting drug pharmacokinetics in space: what do we really know? A critical review of the literature.British journal of pharmacology · 2022Review
- Understanding the Complexities and Changes of the Astronaut Microbiome for Successful Long-Duration Space Missions.Life (Basel, Switzerland) · 2022Review
- Systemic effects of BMP2 treatment of fractures on non-injured skeletal sites during spaceflight.Frontiers in endocrinology · 2022Article
- Key points for the development of antioxidant cocktails to prevent cellular stress and damage caused by reactive oxygen species (ROS) during manned space missions.NPJ microgravity · 2021Review
- Dragon's Blood Regulates Rac1-WAVE2-Arp2/3 Signaling Pathway to Protect Rat Intestinal Epithelial Barrier Dysfunction Induced by Simulated Microgravity.International journal of molecular sciences · 2021Article
- Oral absorption and drug interaction kinetics of moxifloxacin in an animal model of weightlessness.Scientific reports · 2021Article
- Effects of Simulated Microgravity on the Proteome and Secretome of the Polyextremotolerant Black FungusFrontiers in genetics · 2021Article
- Phase 0/microdosing approaches: time for mainstream application in drug development?Nature reviews. Drug discovery · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Medications have been used during space missions for more than half a century, yet our understanding of the effects of spaceflight on drug pharmacokinetics and pharmacodynamics is poor. The space environment induces time-dependent alterations in human physiology that include fluid shifts, cardiovascular deconditioning, bone and muscle density loss, and impaired immunity. This review presents the current knowledge on the physiological effects of spaceflight that can translate into altered drug disposition and activity and eventually to inadequate treatment. It describes findings from studies in astronauts along with mechanistic studies in animal models and in vitro systems. Future missions into deeper space and the emergence of commercial spaceflight will require a more detailed understanding of space pharmacology to optimize treatment in astronauts and space travelers.
Indexed as
Identifiers
31414302What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.