Evidence map›Paper›PMID 31414232›Full record

ArticleJournal of materials science. Materials in medicine2019

Resorption of the calcium phosphate layer on S53P4 bioactive glass by osteoclasts.

Nicole A P van Gestel, Gerke H Schuiringa, Juul H P H Hennissen, Anneke C A Delsing, Keita Ito, Bert van Rietbergen, Jacobus J Arts, Sandra Hofmann

Abstract read
In one paragraph

Article in Journal of materials science. Materials in medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. How Bioactive Glass S53P4 Kills Bacteria.Journal of functional biomaterials · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nicole A P van GestelOrthopaedic Biomechanics, Department of Biomedical Engineering, Eindhoven University of Technology, PO Box 513, 5600 MB, Eindhoven, The Netherlands.
Gerke H SchuiringaOrthopaedic Biomechanics, Department of Biomedical Engineering, Eindhoven University of Technology, PO Box 513, 5600 MB, Eindhoven, The Netherlands.
Juul H P H HennissenFaculty Bèta Sciences and Technology, Zuyd University of Applied Sciences, PO Box 550, 6400 AN, Heerlen, The Netherlands.
Anneke C A DelsingDepartment of the Built Environment, Building Physics and Services, Eindhoven University of Technology, PO Box 513, 5600 MB, Eindhoven, The Netherlands.
Keita ItoOrthopaedic Biomechanics, Department of Biomedical Engineering, Eindhoven University of Technology, PO Box 513, 5600 MB, Eindhoven, The Netherlands.
Bert van RietbergenOrthopaedic Biomechanics, Department of Biomedical Engineering, Eindhoven University of Technology, PO Box 513, 5600 MB, Eindhoven, The Netherlands.
Jacobus J ArtsOrthopaedic Biomechanics, Department of Biomedical Engineering, Eindhoven University of Technology, PO Box 513, 5600 MB, Eindhoven, The Netherlands.
Sandra HofmannOrthopaedic Biomechanics, Department of Biomedical Engineering, Eindhoven University of Technology, PO Box 513, 5600 MB, Eindhoven, The Netherlands. s.hofmann.boss@tue.nl.ORCID http://orcid.org/0000-0002-2568-8388

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clinically, S53P4 bioactive glass (BAG) has shown very promising results in bone infection treatment, but it is also known to degrade very slowly in vivo. To evaluate which mechanisms (cellular or dissolution) can play a role in the degradation of S53P4 BAG and S53P4 BAG putty, in vitro degradation experiments at different pH (7.4 and 4.6) were performed. Micro computed tomography showed a rapid dissolution of the synthetic binder in the putty formulation, within 12 h is simulated body fluid (pH = 7.4), leaving behind only loose granules. Therefore the degradation of the loose granules was investigated further. Significant weight loss was observed and ion chromatography showed that Ca

Indexed as

Absorbable ImplantsGlassAdsorptionBone SubstitutesCalcium PhosphatesCell DifferentiationCells, CulturedHumansMaterials TestingMonocytesOsteoclastsbioactive glass S53P4Bone Substitutescalcium phosphateCalcium Phosphates

Identifiers

PMID31414232
PMCPMC6694093

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.