Evidence map›Paper›PMID 31414212›Full record

ReviewEuropean journal of pediatrics2019

Decision-making for pediatric allergy immunotherapy for aeroallergens: a narrative review.

Miguel Tortajada-Girbés, María Mesa Del Castillo, Helena Larramona, José Manuel Lucas, Montserrat Álvaro Lozano, Ana Isabel Tabar, Begoña Soler López, Ana Martínez-Cañavate, Immunotherapy Working Group of the Spanish Society of Pediatric Clinical Immunology and Allergology (SEICAP)

Abstract readReview
PubMed Publisher
In one paragraph

Review in European journal of pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Determination of immunogenic epitopes in major house dust mite allergen, Der p 2, via nanoallergens.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2022
    Article
  2. Article
  3. Review
  4. VALIDA project: Validation of allergyAdvances in laboratory medicine · 2020
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 8 institutions in 1 country.

Miguel Tortajada-GirbésPaediatric Allergology and Pulmonology Unit, Dr. Peset University Hospital, Valencia, Spain.
María Mesa Del CastilloPaediatric Allergology and Neumology Unit, Hospital El Escorial, Madrid, Spain.
Helena LarramonaPaediatric Allergology and Pulmonology Unit, Department of Paediatrics, University Autonoma of Barcelona, and Corporacio Sanitaria Parc Tauli, Hospital of Sabadell, Barcelona, Spain.
José Manuel LucasPediatric Allergy and Immunology Unit, Virgen Arrixaca Clinic Universitary Hospital, Murcia, Spain.
Montserrat Álvaro LozanoAllergy and Clinical Immunology Section, Hospital Sant Joan de Déu, Universitat de Barcelona, Barcelona, Spain.
Ana Isabel TabarComplejo Hospitalario de Navarra; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain.
Begoña Soler LópezMedical Department, E-C-BIO, S.L., c/ Rosa de Lima, 1, Edificio ALBA, Office 016, Las Rozas, 28230, Madrid, Spain. bsoler@ecbio.net.ORCID http://orcid.org/0000-0001-5853-2307
Ana Martínez-CañavatePaediatric Allergology and Neumology Unit, Complejo Hospitalario Universitario de Granada, Coordinator of the SEICAP Immunotherapy Working Group, Granada, Spain.
Immunotherapy Working Group of the Spanish Society of Pediatric Clinical Immunology and Allergology (SEICAP)
Complejo Hospitalario de Navarra · ESComplejo Hospitalario Universitario de Granada · ESCorporació Sanitària Parc Taulí · ESHospital El Escorial · ESHospital Sant Joan de Déu Barcelona · ESHospital Universitario Virgen de la Arrixaca · ESMadrid Institute for Advanced Studies · ESUniversitat de València · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There has been exciting progress in diagnosis and in the treatment of allergic patients. The objective of this review is to summarize the most relevant contributions in the past 10 years with a special focus on the pediatric population allergic to aeroallergens and provide the most relevant references and practical issues for the decision-making. Current guidelines on allergy diagnosis recommend a thorough clinical history as the first step, followed by allergen extract testing using an in vivo prick test and/or an in vitro specific IgE test. Molecular diagnosis is recommended when previous tests are inconclusive. In practice, the most important factors to decide the AIT treatment are the actual intensity and duration of the patient's symptoms and the availability of appropriate AIT products for the patient's sensitization profile at high allergen concentrations and with confirmed efficacy and safety from clinical trials. This document summarizes outstanding references for allergic immunotherapy decision-making and provides summary tables and figures analyzing the most important factors related to the decision for allergen immunotherapy and the safety risks related. The experts concluded that AIT is efficacious and safe for the treatment of allergic patients that is available for the most frequent aeroallergens.What is Known:• The prevalence of allergic asthma and rhinitis in children has increased in recent decades.• The efficacy and safety of allergen immunotherapy has been shown in multiple studies and systematic reviews.What is New:• This document summarizes outstanding references for allergic immunotherapy decision-making and provides summary tables and figures analyzing the most important factors related to the decision for allergen immunotherapy and the safety risks related. Recommendations of expert authors for the decision of the patients more suitable for allergen immunotherapy are included.

Indexed as

Decision MakingDesensitization, ImmunologicAllergensChildHumansInhalation ExposureAllergensAeroallergensAllergen immunotherapyAllergic rhinitisAsthmaSubcutaneous immunotherapySublingual immunotherapy

Identifiers

PMID31414212
OpenAlexW2968891386

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.