Evidence map›Paper›PMID 31414171›Full record

ArticlePediatric surgery international2019

A new approach using image analysis to assess pulmonary hypoplasia in the fetal lamb diaphragmatic hernia model.

Takuya Kawaguchi, Kohei Kawaguchi, Juma Obayashi, Kunihide Tanaka, Kei Ohyama, Yasuji Seki, Hideki Nagae, Shigeyuki Furuta, Kevin C Pringle, Hiroaki Kitagawa

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Article in Pediatric surgery international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Takuya KawaguchiDivision of Pediatric Surgery, St. Marianna University School of Medicine, 2-16-1, Sugao, Miyamae-ku, Kawasaki, Kanagawa, 2168511, Japan. t2kawaguchi@marianna-u.ac.jp.
Kohei KawaguchiDivision of Pediatric Surgery, St. Marianna University School of Medicine, 2-16-1, Sugao, Miyamae-ku, Kawasaki, Kanagawa, 2168511, Japan.
Juma ObayashiDivision of Pediatric Surgery, St. Marianna University School of Medicine, 2-16-1, Sugao, Miyamae-ku, Kawasaki, Kanagawa, 2168511, Japan.
Kunihide TanakaDivision of Pediatric Surgery, St. Marianna University School of Medicine, 2-16-1, Sugao, Miyamae-ku, Kawasaki, Kanagawa, 2168511, Japan.
Kei OhyamaDivision of Pediatric Surgery, St. Marianna University School of Medicine, 2-16-1, Sugao, Miyamae-ku, Kawasaki, Kanagawa, 2168511, Japan.
Yasuji SekiDivision of Pediatric Surgery, St. Marianna University School of Medicine, 2-16-1, Sugao, Miyamae-ku, Kawasaki, Kanagawa, 2168511, Japan.
Hideki NagaeDivision of Pediatric Surgery, St. Marianna University School of Medicine, 2-16-1, Sugao, Miyamae-ku, Kawasaki, Kanagawa, 2168511, Japan.
Shigeyuki FurutaDivision of Pediatric Surgery, St. Marianna University School of Medicine, 2-16-1, Sugao, Miyamae-ku, Kawasaki, Kanagawa, 2168511, Japan.
Kevin C PringleDepartment of Obstetrics and Gynecology, School of Medicine and Health Sciences, University of Otago, Wellington, New Zealand.
Hiroaki KitagawaDivision of Pediatric Surgery, St. Marianna University School of Medicine, 2-16-1, Sugao, Miyamae-ku, Kawasaki, Kanagawa, 2168511, Japan.
St. Marianna University School of Medicine · JPUniversity of Otago · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn congenital diaphragmatic hernia (CDH), there is pulmonary hypoplasia (PH) and also pulmonary vascular and bronchial abnormalities. Few studies have investigated bronchial maldevelopment in CDH. We evaluated bronchial area (BA) by bronchography in a fetal lamb DH model to develop a measure of PH.

methodsWe created DH in fetal lambs at 75 days gestation, delivering by cesarean section and killing them at term (DH, n = 12). Normal term fetuses provided controls (C, n  = 5). We measured total lung volume (TLV) and performed barium bronchography. Using image analysis, BA, total lung area (TLA) and bronchial area/lung area ratio (B/L ratio) were calculated. Student's T test (p < 0.05; significant) and Spearman's correlation coefficient were performed.

resultsTLV (ml) was 133.3 ± 41.2 in DH and 326 ± 22.5 in C (p = 0.0000001). TLA (cm

conclusionIt may be possible to assess PH on fetal MRI, given the correlation between TLV and TLA, and TLV and BA.

Indexed as

Abnormalities, MultiplePregnancy, AnimalAnimalsAnimals, NewbornDisease Models, AnimalFemaleHernias, Diaphragmatic, CongenitalLungLung DiseasesMagnetic Resonance ImagingPregnancyPrenatal DiagnosisSheepBronchial abnormalitiesCDHCongenital diaphragmatic herniaImage analysisPulmonary hypoplasia

Identifiers

PMID31414171
OpenAlexW2967247887

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.