ArticleBMJ paediatrics open2019
Nasal high-frequency oscillatory ventilation (nHFOV) versus nasal continuous positive airway pressure (NCPAP) as an initial therapy for respiratory distress syndrome (RDS) in preterm and near-term infants.
Article in BMJ paediatrics open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04914715 (Effectiveness of Non-invasive High Frequency Oscillatory Ventilation), which is not on this map. Cited by 16 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness of Non-invasive High Frequency Oscillatory Ventilation (nHFOV) Versus Invasive Conventional Ventilation for Preterm Neonates With Respiratory Distress Syndrome
Who cites it
16 citing papers in PubMed, 4 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Nasal high-frequency oscillatory ventilation versus nasal continuous positive airway pressure for respiratory distress syndrome in preterm infants: A systematic review and meta-analysis.European journal of pediatrics · 2026Pooled it
- Non-invasive respiratory support in preterm infants as primary mode: a network meta-analysis.The Cochrane database of systematic reviews · 2025Pooled it
- Non-invasive high-frequency ventilation in newborn infants with respiratory distress.The Cochrane database of systematic reviews · 2024Pooled it
- Nasal high-frequency oscillatory ventilation versus nasal continuous positive airway pressure as primary respiratory support strategies for respiratory distress syndrome in preterm infants: a systematic review and meta-analysis.European journal of pediatrics · 2022Pooled it
- Non-invasive high-frequency oscillation ventilation versus nasal CPAP as primary respiratory support in preterm neonates ≥ 30 weeks with RDS: a non-inferiority randomized controlled trial.European journal of pediatrics · 2026Trial
- High-Frequency Oscillatory Ventilation Combined With Inhaled Nitric Oxide for Persistent Pulmonary Hypertension of the Newborn: A Single-Center Randomized Clinical Trial.Canadian respiratory journal · 2026Trial
- Non-invasive high frequency oscillatory ventilation for primary respiratory support in extremely preterm infants: multicentre randomised controlled trial.BMJ (Clinical research ed.) · 2025Trial
- Outcomes and complications of invasive versus non-invasive respiratory support in extremely preterm infants: a retrospective study.BMC pediatrics · 2026Article
- Proportion of confluent B-Lines predicts respiratory support in term infants shortly after birth.Respiratory research · 2024Observational
- Article
- The long-term outcomes of preterm infants receiving non-invasive high-frequency oscillatory ventilation.Frontiers in pediatrics · 2022Article
- The Intertemporal Role of Respiratory Support in Improving Neonatal Outcomes: A Narrative Review.Children (Basel, Switzerland) · 2021Review
- Nasal high-frequency jet ventilation (NHFJV) as a novel means of respiratory support in extremely low birth weight infants.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- Practical aspects on the use of non-invasive respiratory support in preterm infants.International journal of pediatrics & adolescent medicine · 2020Review
- Three non-invasive ventilation strategies for preterm infants with respiratory distress syndrome: a propensity score analysis.Archives of medical science : AMS · 2020Article
- Non-invasive Respiratory Support of the Premature Neonate: From Physics to Bench to Practice.Frontiers in pediatrics · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCurrently, various forms of non-invasive respiratory support have been used in the management of respiratory distress syndrome (RDS) in preterm neonates. However, nasal high-frequency oscillatory ventilation (nHFOV) has not yet been applied commonly as an initial treatment.
objectivesThis study was designed to investigate the efficacy and safety of nHFOV compared with nasal continuous positive airway pressure (NCPAP) in preterm and near-term infants with RDS.
methodsIn a randomised clinical trial, a total of 68 neonates (gestational age (GA) between 30 and 36 weeks and 6 days) with a clinical diagnosis of RDS were randomly assigned to either the NCPAP (n=34) or the nHFOV (n=34) group. The primary outcome was the duration of non-invasive respiratory support (duration of using NCPAP or nHFOV).
resultThe median (IQR) duration of non-invasive respiratory support, was significantly shorter in the nHFOV group than that in the NCPAP group (20 (15-25.3) versus 26.5 (15-37.4) hours, respectively; p=0.02). The need for a ventilator occurred in 4 out of 34 (11.8%) neonates in the NCPAP group and in none of the neonates in the nHFOV group (p=0.03). In addition, intraventricular haemorrhage (IVH) occurred in nine cases (6.9%) in the NCPAP group and two cases (3.3%) in the nHFOV group, which showed a significant difference (p=0.04). The incidence of pneumothorax, chronic lung disease, pulmonary haemorrhage and necrotising enterocolitis was similar between the two groups.
conclusionThis study showed that nHFOV significantly reduced the duration of non-invasive respiratory support and decreased the need for intubation compared with NCPAP in infants with RDS. Furthermore, nHFOV seems to reduce the incidence of IVH without increasing other complications. TRIAL REGISTRATION NUMBER: IRCT2017062734782N1.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.