ReviewTranslational pediatrics2019
The clinical management and outcomes of extremely preterm infants in Japan: past, present, and future.
Review in Translational pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
70 citing papers in PubMed, 1 synthesis or guideline pooled it, 131 citations in OpenAlex.
- Pooled it
- Cardiopulmonary Ultrasound-Guided Treatment of Premature Infants with Respiratory Failure and Patent Ductus Arteriosus: A Randomized, Controlled Trial.Indian journal of pediatrics · 2023Trial
- Mortality and morbidity in very preterm infants in Switzerland spanning 16 years (2006-2021).BMJ paediatrics open · 2026Article
- Spatial analysis of cross-boundary hospitalizations of very low birth weight infants in Japan.Pediatric research · 2026Article
- Caring for the smallest hearts: cardiovascular phenotypes and assessment in tiny babies.Pediatric research · 2026Review
- Outcomes of early-phase ampicillin plus aminoglycosides versus ampicillin plus cefotaxime for preterm infants.Pediatric research · 2026Article
- Growth and safety evaluation in very low birth weight infants receiving an exclusive human milk diet: a phase III randomized control trial in Japan.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Perspectives of medical staff on respiratory management with neurally adjusted ventilatory assist in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Midwife-Led Home Births in Japan: A 25-Year Retrospective Analysis of Care in Accordance with WHO Recommendations Before and After COVID-19.Healthcare (Basel, Switzerland) · 2026Article
- Levels of care for maternal and neonatal healthcare: a scoping review.Journal of global health · 2026Article
- Impact of ultrasound-guided circulatory management protocol on intraventricular hemorrhage in extremely preterm infants.Pediatric research · 2026Article
- Association between betamimetics tocolysis duration and maternal adverse events: a national real-world data analysis from Japan.Scientific reports · 2026Article
- Implementation of Disaster Prevention Education and Maternal and Child Health Handbook Guidance for Pregnant Women in Japanese Medical Institutions: A Pilot Study.Nursing reports (Pavia, Italy) · 2026Article
- Birth Weight-Dependent Regional Disparities in 28-Day and 1-Year Survival of Preterm Infants: Seoul Capital Area vs. Non-Capital Regions, South Korea, 2002-2021.Children (Basel, Switzerland) · 2026Article
- Article
- Association of low progesterone levels and periodontal disease with threatened preterm labor.Scientific reports · 2026Article
- Family integrated care to improve evidence-based practices for preterm infants in the neonatal intensive care unit: a meta-analysis and systematic review.BMC nursing · 2026Article
- Case Report: Urachal calculus with an atypical intravesical CT appearance and literature review.Frontiers in urology · 2026Article
- Hemodynamic evaluation following ductal closure and association with IVH in premature infants born at 22-23weeks gestation.Frontiers in pediatrics · 2026Article
- Lung ultrasound for predicting surfactant administration in ventilated and non-ventilated infants with respiratory distress syndrome: a multicenter prospective study.European journal of pediatrics · 2025Observational
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is a wide variation in neonatal mortality rates across regions and countries. Japan has one of the lowest neonatal mortality rates in the world; in particular, the mortality rate of extremely preterm infants (i.e., those born before 26 weeks of gestation) is much lower in Japan than in other developed countries. In addition, Japan has low incidences of intraventricular hemorrhage, necrotizing enterocolitis, and late-onset sepsis, a very high incidence of retinopathy of prematurity, and a relatively high incidence of chronic lung disease. In Japan, general perinatal medical centers (PMCs), which are PMCs that offer the highest levels of care, are required to have an obstetric department with maternal-fetal intensive care units as well as a neonatal or pediatric department with neonatal intensive care units (NICU), in order to promote antenatal rather than neonatal maternal transfer of high-risk cases. The limit of viability of extremely preterm infants is 22 weeks of gestation, and approximately half of them are estimated to receive active resuscitation. The clinical management of extremely preterm infants in Japan are characterized by (I) circulatory management that is guided by neonatologist-performed echocardiography, (II) relatively invasive respiratory management, (III) nutritional management, which entails the promotion of breast milk feeding, early enteral feeding, routine glycerin enema, and the administration of probiotics, (IV) neurological management by means of minimal handling, sedation of ventilated infants, and serial brain ultrasounds, and (V) infection control with the assistance of serial C-reactive protein (CRP) monitoring. Thus, this review provides a brief description of the development of neonatology in Japan, introduces the unique features of Japanese clinical management of extremely preterm infants, and overviews their outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.