ReviewTissue engineering and regenerative medicine2019
Perspective on Intra-articular Injection Cell Therapy for Osteoarthritis Treatment.
Review in Tissue engineering and regenerative medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Benefits of Applying Nanotechnologies to Hydrogels in Efficacy Tests in Osteoarthritis Models-A Systematic Review of Preclinical Studies.International journal of molecular sciences · 2022Pooled it
- Intra-articular dual-targeted hydrogel co-delivering diacerein nanoparticles and ketorolac for modulating neuroimmune interplay and cartilage degeneration in osteoarthritis.Drug delivery and translational research · 2026Article
- Considerations in modern regenerative medicine for osteoarthritis.EFORT open reviews · 2025Article
- Progressing future osteoarthritis treatment toward precision medicine: integrating regenerative medicine, gene therapy and circadian biology.Experimental & molecular medicine · 2025Review
- Review
- Anti-Osteoarthritic Effects of Cartilage-Derived Extracellular Matrix in a Rat Osteoarthritis Model.Tissue engineering and regenerative medicine · 2023Article
- Mitochondrial Calcium Nanoregulators Reverse the Macrophage Proinflammatory Phenotype Through Restoring Mitochondrial Calcium Homeostasis for the Treatment of Osteoarthritis.International journal of nanomedicine · 2023Article
- Human Fetal Cartilage-Derived Progenitor Cells Exhibit Anti-Inflammatory Effect on IL-1β-Mediated Osteoarthritis Phenotypes In Vitro.Tissue engineering and regenerative medicine · 2022Article
- Circular RNA CREBBP modulates cartilage degradation by activating the Smad1/5 pathway through the TGFβ2/ALK1 axis.Experimental & molecular medicine · 2022Article
- Emerging Concepts of Endotypes/Phenotypes in Regenerative Medicine for Osteoarthritis.Tissue engineering and regenerative medicine · 2022Article
- Article
- Evaluation of the Usefulness of Human Adipose-Derived Stem Cell Spheroids Formed Using SphereRingCells · 2022Article
- Engineered M2a macrophages for the treatment of osteoarthritis.Frontiers in immunology · 2022Article
- PTX-3 Secreted by Intra-Articular-Injected SMUP-Cells Reduces Pain in an Osteoarthritis Rat Model.Cells · 2021Article
- Exosomes from IL-1β-Primed Mesenchymal Stem Cells Inhibited IL-1β- and TNF-α-Mediated Inflammatory Responses in Osteoarthritic SW982 Cells.Tissue engineering and regenerative medicine · 2021Article
- Current status of regenerative medicine in osteoarthritis.Bone & joint research · 2021Article
- Overcoming Current Dilemma in Cartilage Regeneration: Will Direct Conversion Provide a Breakthrough?Tissue engineering and regenerative medicine · 2020Review
- Regenerative Therapy for Osteoarthritis: A Perspective.International journal of stem cells · 2020Review
- General population knowledge about osteoarthritis and its related risk factors in Jeddah Saudi Arabia.Saudi medical journal · 2020Article
- Updates in Cartilage Tissue Regeneration.Tissue engineering and regenerative medicine · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Osteoarthritis (OA), the most common arthritis, is one of the most frequently encountered orthopaedic conditions. As a small number of large joints such as knee and hip are affected in OA, OA is an ideal target for local therapy. Although corticosteroid and hyaluronic acid have been traditionally used for joints through intra-articular (IA) injection, IA injection also provides a minimally invasive route to apply cell therapy to treat OA. IA cell therapy has drawn attention because it may provide regeneration of articular cartilage in addition to palliative anti-inflammatory effects. Methods: Current progress of IA injection therapy and the author's perspective on this issue are described narratively. Results: It is too premature to have any conclusion on the eventual efficacy of IA cell therapy concerning regeneration of articular cartilage based on current data. Prospective radiological and histological data from larger numbers of patients are needed to prove cost effectiveness of IA cell therapy. Conclusions: Expanding research in this field will produce further evidences to provide guidance on the eventual effectiveness of IA cell therapy in the future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.