Evidence map›Paper›PMID 31413731›Full record

ReviewTherapeutic advances in medical oncology2019

Opportunities for cannabis in supportive care in cancer.

Amber S Kleckner, Ian R Kleckner, Charles S Kamen, Mohamedtaki A Tejani, Michelle C Janelsins, Gary R Morrow, Luke J Peppone

Open access · goldAbstract readReview
In one paragraph

Review in Therapeutic advances in medical oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 3 pooled it
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 3 syntheses or guidelines pooled it, 85 citations in OpenAlex.

  1. Cannabis use among cancer survivors: a systematic review and meta-analysis.Archives of public health = Archives belges de sante publique · 2026
    Pooled it
  2. Pooled it
  3. Cannabis-based medicines and medical cannabis for adults with cancer pain.The Cochrane database of systematic reviews · 2023
    Pooled it
  4. Article
  5. Article
  6. Article
  7. Implementing Ryan's Law on an Inpatient Medical Oncology Unit.Clinical journal of oncology nursing · 2025
    Article
  8. Cannabis and cannabinoid research · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Current cannabis use and pain management among US cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Amber S KlecknerCancer Control and Survivorship, University of Rochester Medical Center, CU 420658, 265 Crittenden Blvd., Rochester, NY 14642, USA.ORCID https://orcid.org/0000-0002-5088-1139
Ian R KlecknerCancer Control and Survivorship, University of Rochester Medical Center, Rochester, NY, USA.
Charles S KamenCancer Control and Survivorship, University of Rochester Medical Center, Rochester, NY, USA.
Mohamedtaki A TejaniDepartment of Medicine, University of Rochester Medical Center, Rochester, NY, USA.
Michelle C JanelsinsCancer Control and Survivorship, University of Rochester Medical Center, Rochester, NY, USA.
Gary R MorrowCancer Control and Survivorship, University of Rochester Medical Center, Rochester, NY, USA.
Luke J PepponeCancer Control and Survivorship, University of Rochester Medical Center, Rochester, NY, USA.
University of Rochester Medical Center · US

Funding

URCC NCORP Research BaseUG1CA189961 · NCI · UNIVERSITY OF ROCHESTER · PI Michelle C Janelsins, KAREN M. MUSTIAN · 2014 to 2026
$67.7M
Clinical and Translational Cancer Control Research Training ProgramT32CA102618 · NCI · UNIVERSITY OF ROCHESTER · PI Michelle C Janelsins, Gary R Morrow · 2019 to 2026
$2.7M
Treatment of Refractory NauseaR01CA200579 · NCI · UNIVERSITY OF ROCHESTER · PI PEPPONE, LUKE JOSEPH · 2016 to 2021
$1.1M
The Effects of Exercise on Chemotherapy-Induced Peripheral Neuropathy, Inflammation, and Interoceptive Brain CircuitryK07CA221931 · NCI · UNIVERSITY OF ROCHESTER · PI KLECKNER, IAN ROBERT · 2018 to 2022
$795k
Management of Cancer-Treatment-Induced Bone LossK07CA168911 · NCI · UNIVERSITY OF ROCHESTER · PI PEPPONE, LUKE JOSEPH · 2013 to 2017
$724k
NCI NIH HHS K07 CA168911NCI NIH HHS K07 CA221931NCI NIH HHS R01 CA200579NCI NIH HHS UG1 CA189961
6 · The paper itself

Abstract

Cannabis has the potential to modulate some of the most common and debilitating symptoms of cancer and its treatments, including nausea and vomiting, loss of appetite, and pain. However, the dearth of scientific evidence for the effectiveness of cannabis in treating these symptoms in patients with cancer poses a challenge to clinicians in discussing this option with their patients. A review was performed using keywords related to cannabis and important symptoms of cancer and its treatments. Literature was qualitatively reviewed from preclinical models to clinical trials in the fields of cancer, human immunodeficiency virus (HIV), multiple sclerosis, inflammatory bowel disease, post-traumatic stress disorder (PTSD), and others, to prudently inform the use of cannabis in supportive and palliative care in cancer. There is a reasonable amount of evidence to consider cannabis for nausea and vomiting, loss of appetite, and pain as a supplement to first-line treatments. There is promising evidence to treat chemotherapy-induced peripheral neuropathy, gastrointestinal distress, and sleep disorders, but the literature is thus far too limited to recommend cannabis for these symptoms. Scant, yet more controversial, evidence exists in regard to cannabis for cancer- and treatment-related cognitive impairment, anxiety, depression, and fatigue. Adverse effects of cannabis are documented but tend to be mild. Cannabis has multifaceted potential bioactive benefits that appear to outweigh its risks in many situations. Further research is required to elucidate its mechanisms of action and efficacy and to optimize cannabis preparations and doses for specific populations affected by cancer.

Indexed as

cancer controlcannabismedical marijuanapalliative caresupportive care

Identifiers

PMID31413731
PMCPMC6676264
OpenAlexW2966495857

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.