Evidence map›Paper›PMID 31413631›Full record

ArticleCancer management and research2019

Cardiovascular disease-related chronic conditions among Veterans Affairs nonmetastatic colorectal cancer survivors: a matched case-control analysis.

Leah L Zullig, Valerie A Smith, Jennifer H Lindquist, Christina D Williams, Morris Weinberger, Dawn Provenzale, George L Jackson, Michael J Kelley, Susanne Danus, Hayden B Bosworth

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer management and research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Leah L ZulligCenter for Health Services Research in Primary Care, Durham Veterans Affairs Health Care System, Durham, NC, USA.
Valerie A SmithCenter for Health Services Research in Primary Care, Durham Veterans Affairs Health Care System, Durham, NC, USA.
Jennifer H LindquistCenter for Health Services Research in Primary Care, Durham Veterans Affairs Health Care System, Durham, NC, USA.
Christina D WilliamsDivision of Medical Oncology, Department of Medicine, Duke University, Durham, NC, USA.
Morris WeinbergerCenter for Health Services Research in Primary Care, Durham Veterans Affairs Health Care System, Durham, NC, USA.
Dawn ProvenzaleCenter for Health Services Research in Primary Care, Durham Veterans Affairs Health Care System, Durham, NC, USA.
George L JacksonCenter for Health Services Research in Primary Care, Durham Veterans Affairs Health Care System, Durham, NC, USA.
Michael J KelleyOffice of Specialty Care Services, Department of Veterans Affairs , Washington, DC, USA.
Susanne DanusCenter for Health Services Research in Primary Care, Durham Veterans Affairs Health Care System, Durham, NC, USA.
Hayden B BosworthCenter for Health Services Research in Primary Care, Durham Veterans Affairs Health Care System, Durham, NC, USA.
Duke University · USDurham VA Health Care System · USDuke Medical Center · USUniversity of North Carolina at Chapel Hill · US

Funding

HSRD VA IK2 HX001345
6 · The paper itself

Abstract

purposeThe growing number of colorectal cancer (CRC) survivors often have multiple chronic conditions. Comparing nonmetastatic CRC survivors and matched noncancer controls, our objectives were to determine the odds of CRC survivors being diagnosed with cardiovascular disease (CVD)-related chronic conditions and their likelihood of control during the year after CRC diagnosis. PATIENTS AND

methodsWe retrospectively identified patients diagnosed with nonmetastatic CRC in the Veterans Affairs health care system from fiscal years 2009 to 2012 and matched each with up to 3 noncancer control patients. We used logistic regression to assess differences in the likelihood of being diagnosed with CVD-related chronic conditions and control between nonmetastatic CRC survivors and noncancer controls.

resultsWe identified 9,758 nonmetastatic CRC patients and matched them to 29,066 noncancer controls. At baseline, 69.4% of CRC survivors and their matched controls were diagnosed with hypertension, 52.4% with hyperlipidemia, and 36.7% with diabetes. Compared to matched noncancer controls, CRC survivors had 57% higher odds of being diagnosed with hypertension (OR=1.57, 95% CI=1.49-1.64) and 7% higher odds of controlled blood pressure (OR=1.07, 95% CI 1.02, 1.13) in the subsequent year. Compared to matched noncancer control patients, CRC survivors had half the odds of being diagnosed with hyperlipidemia (OR=0.50, 95% CI=0.48-0.52) and lower odds of low-density lipoprotein (LDL) control (OR 0.88, 95% CI 0.81-0.94). There were no significant differences between groups for diabetes diagnoses or control.

conclusionCompared to noncancer controls, nonmetastatic CRC survivors have 1) greater likelihood of being diagnosed with hypertension and worse blood pressure control in the year following diagnosis; 2) lower likelihood of being diagnosed with hyperlipidemia or LDL control; and 3) comparable diabetes diagnoses and control. There may be a need for hypertension control interventions targeting cancer survivors.

Indexed as

cancer survivorscardiovascular diseasechronic disease managementcolorectal neoplasmscomorbidityVeterans Affairs

Identifiers

PMID31413631
PMCPMC6659791
OpenAlexW2963968940

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.