ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2019
Plausible relationship between homocysteine and obesity risk via
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Associations of Dietary Vitamin C and E Intake With Depression. A Meta-Analysis of Observational Studies.Frontiers in nutrition · 2022Pooled it
- MTHFR polymorphisms (rs1801133) and systemic lupus erythematosus risk: A meta-analysis.Medicine · 2020Pooled it
- Evidence on the causal link between homocysteine and hypertension from a meta-analysis of 40 173 individuals implementing Mendelian randomization.Journal of clinical hypertension (Greenwich, Conn.) · 2019Pooled it
- Editorial: Investigating the roles of nutritional determinants, genetic predispositions, and environmental risk factors in the development of obesity and associated metabolic disorders.Frontiers in nutrition · 2026Article
- Homocysteine is a risk factor for reduced ejection fraction in children with myocarditis: a single-center study.Frontiers in pediatrics · 2026Article
- Evaluation of Total Homocysteine Levels in Relation to Abdominal Fat Mass and Traditional Cardiovascular Risk Factors in Overweight and Obese Adolescents.Life (Basel, Switzerland) · 2025Article
- MTHFR Gene Polymorphisms: A Single Gene with Wide-Ranging Clinical Implications-A Review.Genes · 2025Review
- Advances in Mendelian Randomization Studies of Obesity Over the Past Decade: Uncovering Key Genetic Mechanisms.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Review
- Investigating the Matrix of Factor V Leiden (G1691A), Factor II Prothrombin (G2021A), MTHFR C677T and A1298G Polymorphisms in Greek Population: A Preliminary Study.Medical sciences (Basel, Switzerland) · 2024Article
- The Future of Obesity Management through Precision Nutrition: Putting the Individual at the Center.Current nutrition reports · 2024Review
- Associations between plasma sulfur amino acids and specific fat depots in two independent cohorts: CODAM and The Maastricht Study.European journal of nutrition · 2023Article
- Review
- Cloning, distribution, and effects of growth regulation of MC3R and MC4R in red crucian carp (Frontiers in endocrinology · 2023Article
- Bi-directional causal effect between vitamin B12 and non-alcoholic fatty liver disease: Inferring from large population data.Frontiers in nutrition · 2023Article
- Relationship between hyperhomocysteinemia and coexisting obesity with low skeletal muscle mass in asymptomatic adult population.Scientific reports · 2022Article
- Inferring causal effects of homocysteine and B-vitamin concentrations on bone mineral density and fractures: Mendelian randomization analyses.Frontiers in endocrinology · 2022Article
- Polymorphisms in geneFrontiers in nutrition · 2022Article
- Causal effects of B vitamins and homocysteine on obesity and musculoskeletal diseases: A Mendelian randomization study.Frontiers in nutrition · 2022Article
- Review
- Commentary: Vitamin C and Metabolic Syndrome: A Meta-Analysis of Observational Studies.Frontiers in nutrition · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveNumerous studies have explored the role of methylenetetrahydrofolate reductase gene (
methodsEligible studies were selected based on several inclusion and exclusion criteria. Correlations between
resultsConsequently, this meta-analysis implemented with Mendelian randomization approach was conducted among 8,622 cases and 29,695 controls. The results indicated that
conclusionsThrough this meta-analysis, we emphasize a strong relationship between Hcy level and obesity by virtue of
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.