Evidence map›Paper›PMID 31413361›Full record

ArticleNature2019

Wnt and TGFβ coordinate growth and patterning to regulate size-dependent behaviour.

Christopher P Arnold, Blair W Benham-Pyle, Jeffrey J Lange, Christopher J Wood, Alejandro Sánchez Alvarado

Abstract read
In one paragraph

Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. Article
  2. Article
  3. Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Article
  6. Investigating the Functions of Hox Genes Using Planarian Asexual Reproduction.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  7. Article
  8. Review
  9. Article
  10. Transitions and trade-offs in regeneration.Nature ecology & evolution · 2023
    Article
  11. Review
  12. Review
  13. Journal of developmental biology · 2023
    Article
  14. Article
  15. Article
  16. Article
  17. Transforming growth factor-β signalling regulates protoscolex formation in theFrontiers in cellular and infection microbiology · 2023
    Article
  18. Review
  19. Article
  20. An insight into planarian regeneration.Cell proliferation · 2022
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Christopher P ArnoldStowers Institute for Medical Research, Kansas City, MO, USA.
Blair W Benham-PyleStowers Institute for Medical Research, Kansas City, MO, USA.
Jeffrey J LangeStowers Institute for Medical Research, Kansas City, MO, USA.
Christopher J WoodStowers Institute for Medical Research, Kansas City, MO, USA.
Alejandro Sánchez AlvaradoStowers Institute for Medical Research, Kansas City, MO, USA. asa@stowers.org.

Funding

The molecular basis of planarian regenerationR37GM057260 · NIGMS · UNIVERSITY OF UTAH · PI SANCHEZ ALVARADO, ALEJANDRO · 2009 to 2018
$2.8M
The molecular basis of planarian regenerationR01GM057260 · NIGMS · UNIVERSITY OF UTAH · PI SANCHEZ ALVARADO, ALEJANDRO · 1998 to 2006
$1.7M
Howard Hughes Medical InstituteNIGMS NIH HHS R01 GM057260NIGMS NIH HHS R37 GM057260
6 · The paper itself

Abstract

Differential coordination of growth and patterning across metazoans gives rise to a diversity of sizes and shapes at tissue, organ and organismal levels. Although tissue size and tissue function can be interdependent

Indexed as

AnimalsBody PatterningBody SizeCentral Nervous SystemMechanoreceptorsPlanariansReproduction, AsexualRNA InterferenceTransforming Growth Factor betaWnt Signaling PathwayTransforming Growth Factor beta

Identifiers

PMID31413361
PMCPMC6872711

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.