Evidence map›Paper›PMID 31413303›Full record

ArticleScientific reports2019

Lateral fluid-percussion injury leads to pituitary atrophy in rats.

Mehwish Anwer, Riikka Immonen, Nick M E A Hayward, Xavier Ekolle Ndode-Ekane, Noora Puhakka, Olli Gröhn, Asla Pitkänen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Mehwish AnwerA. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Riikka ImmonenA. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Nick M E A HaywardA. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Xavier Ekolle Ndode-EkaneA. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Noora PuhakkaA. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Olli GröhnA. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Asla PitkänenA. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland. asla.pitkanen@uef.fi.
University of Eastern Finland · FI

Funding

The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx) Public Engagement CoreU54NS100064 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ENGEL, JEROME NONE, GALANOPOULOU, ARISTEA S · 2017 to 2021
$21.7M
NINDS NIH HHS U54 NS100064
6 · The paper itself

Abstract

Traumatic brain injury (TBI) causes neuroendocrine dysregulation in up to 40% of humans, which is related to impaired function of the hypothalamo-hypophyseal axis and contributes to TBI-related co-morbidities. Our objective was to investigate whether hypophyseal atrophy can be recapitulated in rat lateral fluid-percussion injury model of human TBI. High-resolution structural magnetic resonance images (MRI) were acquired from rats at 2 days and 5 months post-TBI. To measure the lobe-specific volumetric changes, manganese-enhanced MRI (MEMRI) scans were acquired from rats at 8 months post-TBI, which also underwent the pentylenetetrazol (PTZ) seizure susceptibility and Morris water-maze spatial memory tests. MRI revealed no differences in the total hypophyseal volume between TBI and controls at 2 days, 5 months or 8 months post-TBI. Surprisingly, MEMRI at 8 months post-TBI indicated a 17% reduction in neurohypophyseal volume in the TBI group as compared to controls (1.04 ± 0.05 mm

Indexed as

AnimalsBrain Injuries, TraumaticConvulsantsDisease Models, AnimalElectroencephalographyHumansMagnetic Resonance ImagingMaleMaze LearningPentylenetetrazolePituitary GlandPrognosisRatsRetrospective StudiesConvulsantsPentylenetetrazole

Identifiers

PMID31413303
PMCPMC6694150
OpenAlexW2967357378

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.