SynthesisNature communications2019
A meta-analysis of genome-wide association studies identifies multiple longevity genes.
Erratum issuedAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 249 papers, 3 of them syntheses that pooled it.
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249citing papers in PubMed, 3 pooled it
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What it found
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Who cites it
249 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Meta-analysis of six dairy cattle breeds reveals biologically relevant candidate genes for mastitis resistance.Genetics, selection, evolution : GSE · 2024Pooled it
- Pooled it
- Reviewing and assessing existing meta-analysis models and tools.Briefings in bioinformatics · 2021Pooled it
- Western Hunter-Gatherer genetic ancestry contributes to human longevity in the Italian population.GeroScience · 2026Article
- Genetic links between multimorbidity and human aging.GeroScience · 2026Article
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- Multi-trait Polygenic Profiling and Survival Free of Dementia and Disability: Results from the Health and Retirement Study.medRxiv : the preprint server for health sciences · 2026Article
- Genetic trade-offs in fertility and longevity explain the maintenance of disease-associated alleles in humans.Nature ecology & evolution · 2026Article
- Evolutionary genetics of ageing.Nature reviews. Genetics · 2026Review
- Oxygenaging: A Physiological Framework for Geroscience.Aging cell · 2026Review
- Exceptional Parental Longevity and Onset of Morbidity and Mortality Across Cohorts.JAMA network open · 2026Article
- Biological Aging, Immune Phenotypes, and Susceptibility to COVID-19 and Sepsis: A Mendelian Randomization Study.Virus research · 2026Article
- Genetically proxied glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide receptor pathway modulation is associated with favorable aging phenotypes: a drug-target Mendelian randomization study.Cardiovascular diabetology · 2026Article
- BioMedGraphica: an all-in-one platform for joint textual biomedical prior knowledge and numeric graph generation.Bioinformatics (Oxford, England) · 2026Article
- Unraveling 'F' factor: towards a genetic-clinical framework for the musculoskeletal-heart crosstalk in metabolic aging.Cardiovascular diabetology · 2026Article
- Resilient Biophysical Phenotype of Memory CD4Immunology · 2026Article
- Article
- Genetic associations with longevity in a Calabrian cohort: an exploratory genome-wide study.GeroScience · 2026Article
- A Multimodal Framework for Organ- and Cell-Resolved Biological Aging and Longevity Intervention Discovery.medRxiv : the preprint server for health sciences · 2026Article
- Data-driven leisure-time physical activity trajectories of over 46 years and their associations with cognition in nonagenarians: a cohort study.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026Article
189 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
84 authors.
Joris DeelenMax Planck Institute for Biology of Ageing, 50866, Cologne, Germany. Joris.Deelen@age.mpg.de.ORCID http://orcid.org/0000-0003-4483-3701
Daniel S EvansCalifornia Pacific Medical Center Research Institute, San Francisco, CA, 94158, USA. DEvans@sfcc-cpmc.net.
Dan E ArkingMcKusick-Nathans Institute of Genetic Medicine, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Niccolò TesiAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, 1007 MB, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-1413-5091
Marianne NygaardThe Danish Aging Research Center, Department of Public Health, University of Southern Denmark, 5000, Odense C, Denmark.ORCID http://orcid.org/0000-0003-0703-2665
Xiaomin LiuBGI-Shenzhen, Shenzhen, 518083, China.ORCID http://orcid.org/0000-0003-2155-3627
Mary K WojczynskiDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, Saint Louis, MO, 63110, USA.
Mary L BiggsDepartment of Biostatistics, University of Washington, Seattle, WA, 98115, USA.
Ashley van der SpekDepartment of Epidemiology, Erasmus MC, 3000 CA, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0001-7136-0159
Gil AtzmonDepartment of Biology, Faculty of Natural Science, University of Haifa, Haifa, 3498838, Israel.
Erin B WareInstitute for Social Research, Survey Research Center, University of Michigan, Ann Arbor, MI, 48104, USA.ORCID http://orcid.org/0000-0003-4731-8158
Chloé SarnowskiDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA.
Albert V SmithSchool of Public Health, Department of Biostatistics, University of Michigan, Ann Arbor, MI, 48109, USA.
Ilkka SeppäläDepartment of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, 33520, Tampere, Finland.ORCID http://orcid.org/0000-0002-5595-2573
Heather J CordellInstitute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, NE1 3BZ, UK.ORCID http://orcid.org/0000-0002-1879-5572
Janina DoseInstitute of Clinical Molecular Biology, Kiel University, 24105, Kiel, Germany.
Najaf AminDepartment of Epidemiology, Erasmus MC, 3000 CA, Rotterdam, The Netherlands.
Alice M ArnoldDepartment of Biostatistics, University of Washington, Seattle, WA, 98115, USA.
Kristin L AyersSema4, a Mount Sinai venture, Stamford, CT, 06902, USA.
Nir BarzilaiDepartments of Medicine and Genetics, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.
Elizabeth J BeckerBioinformatics Program, Boston University, Boston, MA, 02118, USA.
Marian BeekmanMolecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands.ORCID http://orcid.org/0000-0003-0585-6206
Hélène BlanchéFondation Jean Dausset-CEPH, 75010, Paris, France.ORCID http://orcid.org/0000-0003-2115-575X
Kaare ChristensenThe Danish Aging Research Center, Department of Public Health, University of Southern Denmark, 5000, Odense C, Denmark.ORCID http://orcid.org/0000-0002-5429-5292
Lene ChristiansenThe Danish Aging Research Center, Department of Public Health, University of Southern Denmark, 5000, Odense C, Denmark.
Joanna C CollertonInstitute of Health & Society, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK.
Sarah CubaynesMMDN, Univ. Montpellier, EPHE, Unité Inserm 1198, PSL Research University, 34095, Montpellier, France.
Steven R CummingsCalifornia Pacific Medical Center Research Institute, San Francisco, CA, 94158, USA.
Karen DaviesInstitute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK.
Birgit DebrabantDepartment of Public Health, University of Southern Denmark, 5000, Odense C, Denmark.
Jean-François DeleuzeFondation Jean Dausset-CEPH, 75010, Paris, France.
Rachel DuncanInstitute of Health & Society, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK.
Jessica D FaulInstitute for Social Research, Survey Research Center, University of Michigan, Ann Arbor, MI, 48104, USA.
Claudio FranceschiDepartment of Applied Mathematics and Centre of Bioinformatics, Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, 603022, Russia.
Pilar GalanEREN, UMR U1153 Inserm/U1125 Inra/Cnam/Paris 13, Université Paris 13, CRESS, 93017, Bobigny, France.ORCID http://orcid.org/0000-0003-1706-3107
Vilmundur GudnasonIcelandic Heart Association, 201, Kópavogur, Iceland.ORCID http://orcid.org/0000-0001-5696-0084
Tamara B HarrisLaboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, MD, 20892, USA.
Martijn HuismanDepartment of Epidemiology and Biostatistics, Vrije Universiteit Amsterdam, Amsterdam UMC, 1007 MB, Amsterdam, The Netherlands.
Mikko A HurmeDepartment of Microbiology and Immunology, Faculty of Medicine and Health Technology, Tampere University, 33014, Tampere, Finland.
Carol JaggerInstitute of Health & Society, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK.ORCID http://orcid.org/0000-0002-6377-9926
Iris JansenAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, 1007 MB, Amsterdam, The Netherlands.
Marja JylhäFaculty of Social Sciences (Health Sciences) and Gerontology Research Center (GEREC), Tampere University, 33104, Tampere, Finland.
Mika KähönenDepartment of Clinical Physiology, Tampere University Hospital and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, 33521, Tampere, Finland.
David KarasikAzrieli Faculty of Medicine, Bar Ilan University, Safed, 13010, Israel.ORCID http://orcid.org/0000-0002-8826-0530
Sharon L R KardiaSchool of Public Health, Epidemiology, University of Michigan, Ann Arbor, MI, 48109, USA.
Andrew KingstonInstitute of Health & Society, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK.
Thomas B L KirkwoodNewcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK.
Lenore J LaunerLaboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, MD, 20892, USA.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, 33520, Tampere, Finland.
Wolfgang LiebInstitute of Epidemiology and Biobank PopGen, Kiel University, 24105, Kiel, Germany.
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, 33520, Tampere, Finland.
Carmen Martin-RuizInstitute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK.ORCID http://orcid.org/0000-0002-3361-6974
Junxia MinInstitute of Translational Medicine, School of Medicine, Zhejiang University, Hangzhou, 311058, China.
Almut NebelInstitute of Clinical Molecular Biology, Kiel University, 24105, Kiel, Germany.
Anne B NewmanDepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA.ORCID http://orcid.org/0000-0002-0106-1150
Chao NieBGI-Shenzhen, Shenzhen, 518083, China.
Ellen A NohrResearch Unit of Gynecology and Obstetrics, Department of Clinical Research, University of Southern Denmark, 5000, Odense C, Denmark.
Eric S OrwollBone and Mineral Unit, Oregon Health Sciences University, Portland, OR, 97239, USA.ORCID http://orcid.org/0000-0002-8520-7355
Thomas T PerlsDepartment of Medicine, Geriatrics Section, Boston Medical Center, Boston University School of Medicine, Boston, MA, 02118, USA.
Michael A ProvinceDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, Saint Louis, MO, 63110, USA.
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, 98101, USA.
Olli T RaitakariDepartment of Clinical Physiology and Nuclear Medicine, Turku University Hospital, 20521, Turku, Finland.
Marcel J T ReindersDelft Bioinformatics Lab, Delft University of Technology, 2600 GA, Delft, The Netherlands.ORCID http://orcid.org/0000-0002-1148-1562
Jean-Marie RobineMMDN, Univ. Montpellier, EPHE, Unité Inserm 1198, PSL Research University, 34095, Montpellier, France.ORCID http://orcid.org/0000-0002-4111-6195
Jerome I RotterInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.ORCID http://orcid.org/0000-0001-7191-1723
Paola SebastianiDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA.
Jennifer SmithInstitute for Social Research, Survey Research Center, University of Michigan, Ann Arbor, MI, 48104, USA.ORCID http://orcid.org/0000-0002-3575-5468
Thorkild I A SørensenNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, and Department of Public Health, Section of Epidemiology, Faculty of Health and Medical Sciences, University of Copenhagen, 2200, Copenhagen N, Denmark.ORCID http://orcid.org/0000-0003-4821-430X
Kent D TaylorInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.ORCID http://orcid.org/0000-0002-2756-4370
André G UitterlindenDepartment of Epidemiology, Erasmus MC, 3000 CA, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-7276-3387
Wiesje van der FlierAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, 1007 MB, Amsterdam, The Netherlands.
Sven J van der LeeAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, 1007 MB, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0003-1606-8643
Cornelia M van DuijnDepartment of Epidemiology, Erasmus MC, 3000 CA, Rotterdam, The Netherlands.
Diana van HeemstDepartment of Gerontology and Geriatrics, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands.
James W VaupelMax Planck Institute for Demographic Research, 18057, Rostock, Germany.
David WeirInstitute for Social Research, Survey Research Center, University of Michigan, Ann Arbor, MI, 48104, USA.ORCID http://orcid.org/0000-0002-1661-2402
Kenny YeDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.ORCID http://orcid.org/0000-0002-1466-855X
Yi ZengCenter for Healthy Aging and Development Studies, National School of Development and Raissun Institute for Advanced Studies, Peking University, 100871, Beijing, China.
Wanlin ZhengCalifornia Pacific Medical Center Research Institute, San Francisco, CA, 94158, USA.
Henne HolstegeAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, 1007 MB, Amsterdam, The Netherlands.
Douglas P KielHinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA, 02131, USA.ORCID http://orcid.org/0000-0001-8474-0310
Kathryn L LunettaDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA.ORCID http://orcid.org/0000-0002-9268-810X
P Eline SlagboomMolecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands. P.Slagboom@lumc.nl.
Joanne M MurabitoNHLBI's and Boston University's Framingham Heart Study, Framingham, MA, 01702, USA. murabito@bu.edu.
Funding
Oregon Clinical and Translational Research Institute - The National COVID Cohort Collaborative (N3C)UL1TR002369 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Cynthia D Morris, Christopher G. Slatore · 2017 to 2026
$78.4MLong Life Family Study: Data Management and Coordinating CenterU01AG023746 · NIA · WASHINGTON UNIVERSITY · PI PROVINCE, MICHAEL A. · 2004 to 2018
$29.2MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MRare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9MCHS research resources for the cardiovascular health of older adultsU01HL130114 · NHLBI · UNIVERSITY OF WASHINGTON · PI BURKE, GREGORY L, KRONMAL, RICHARD A · 2016 to 2019
$6.6MRare variants and NHLBI traits in deeply phenotyped cohortsU01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2017 to 2018
$5.6MIntegrative Resource to Develop Translational Strategies to Promote LongevityU24AG051129 · NIA · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI CUMMINGS, STEVEN RON, EVANS, DANIEL SPENCER · 2015 to 2019
$5.3MDNA Methylation, Genetics, and Modifiable Risk Factors of Dementia in a Nationally Representative, Multi-Ethnic Cohort - Diversity SupplementR01AG067592 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BAKULSKI, KELLY, WARE, ERIN BAKSHIS · 2020 to 2025
$3.8MCharacterizing disparities in late-onset Alzheimer's disease risk through polygenic risk and epidemiologic factors in the Health and Retirement SurveyR01AG055406 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BAKULSKI, KELLY, WARE, ERIN BAKSHIS · 2017 to 2020
$1.7MAcquisition of a Scalable Storage Cluster for Data Intensive NIH ResearchS10OD016290 · OD · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI GIRKE, THOMAS · 2014 to 2014
$593kMedical Research Council G0500997Medical Research Council MR/J50001X/1NCATS NIH HHS UL1 TR002369NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL120393NHLBI NIH HHS U01 HL120393NHLBI NIH HHS U01 HL130114NIA NIH HHS R01 AG055406NIA NIH HHS R01 AG067592NIA NIH HHS U01 AG023746NIA NIH HHS U24 AG051129NIH HHS S10 OD016290NIMHD NIH HHS L60 MD012145Wellcome Trust 102858/Z/13/Z
Abstract
Human longevity is heritable, but genome-wide association (GWA) studies have had limited success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity phenotype definition including 11,262/3484 cases surviving at or beyond the age corresponding to the 90th/99th survival percentile, respectively, and 25,483 controls whose age at death or at last contact was at or below the age corresponding to the 60th survival percentile. Consistent with previous reports, rs429358 (apolipoprotein E (ApoE) ε4) is associated with lower odds of surviving to the 90th and 99th percentile age, while rs7412 (ApoE ε2) shows the opposite. Moreover, rs7676745, located near GPR78, associates with lower odds of surviving to the 90th percentile age. Gene-level association analysis reveals a role for tissue-specific expression of multiple genes in longevity. Finally, genetic correlation of the longevity GWA results with that of several disease-related phenotypes points to a shared genetic architecture between health and longevity.
Indexed as
Apolipoprotein E2Apolipoprotein E4Endoplasmic Reticulum Chaperone BiPGenome-Wide Association StudyHeat-Shock ProteinsHumansLongevityApolipoprotein E2Apolipoprotein E4Endoplasmic Reticulum Chaperone BiPHeat-Shock ProteinsHSPA5 protein, human
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