ArticleAging2019
Identification and characterization of telocytes in rat testis.
Article in Aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- An Enriched Primary Culture Reveals Morphological Heterogeneity of Rat Testicular Telocytes.Cells · 2026Article
- Identification and localization of telocyte-like cells in human umbilical cord stroma.Scientific reports · 2025Article
- Telocytes: history, origin, identification, structure, distribution, and functions.Histochemistry and cell biology · 2025Review
- Possible protective effects of vanillin against stress-induced seminiferous tubule injury via modulation of Nrf2 and ZO1.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Morphological characteristics and distribution identification of telocytes in Tibetan sheep testis and epididymis.Scientific reports · 2024Article
- Single-cell transcriptome profiling highlights the importance of telocyte, kallikrein genes, and alternative splicing in mouse testes aging.Scientific reports · 2024Article
- Insights on Platelet-Derived Growth Factor Receptor α-Positive Interstitial Cells in the Male Reproductive Tract.International journal of molecular sciences · 2024Review
- Telocytes of the male reproductive system: dynamic tissue organizers.Frontiers in cell and developmental biology · 2024Review
- Morphological and histochemical identification of telocytes in adult yak epididymis.Scientific reports · 2023Article
- Telocytes and Other Interstitial Cells 2.0: From Structure to Function.International journal of molecular sciences · 2022Article
- Behavior and Functional Roles of CD34International journal of molecular sciences · 2022Review
- Telocytes in the esophageal wall of chickens: a tale of subepithelial telocytes.Poultry science · 2022Article
- Effects of Cadmium Exposure on Leydig Cells and Blood Vessels in Mouse Testis.International journal of environmental research and public health · 2022Article
- Myotendinous Junction: Exercise Protocols Can Positively Influence Their Development in Rats.Biomedicines · 2022Article
- VCAM1-α4β1 integrin interaction mediates interstitial tissue reconstruction in 3-D re-aggregate culture of dissociated prepubertal mouse testicular cells.Scientific reports · 2021Article
- Identification of PDGFRα-positive interstitial cells in the distal segment of the murine vas deferens.Scientific reports · 2021Article
- Review
- Myotendinous junction adaptations to ladder-based resistance training: identification of a new telocyte niche.Scientific reports · 2020Article
- Simulation and Modeling of Telocytes Behavior in Signaling and Intercellular Communication Processes.International journal of molecular sciences · 2020Article
- Identification of Telocytes in the Pancreas of Turtles-A role in Cellular Communication.International journal of molecular sciences · 2020Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we investigated the localization, morphological features and cellular interactions of telocytes in the rat testicular interstitium. Transmission electron microscopy (TEM) and immunohistochemical and immunofluorescence analyses of the rat testicular interstitium showed a distinct layer of telocytes surround the seminiferous tubules along with inner layer of peritubular myoid cells. The majority of the telocytes were made up of a small cell body and moniliform prolongations that contained mitochondria and secretory vesicles. Some other telocytes were observed possessing large cell bodies. Within the testicular interstitium, the telocytes formed a network connecting peritubular myoid cells, Leydig cells as well as blood vessels. Immunohistochemical and double immunofluorescence analyses showed that rat testicular telocytes express CD34 and PDGFRα, but are negative for vimentin and α-SMA. Our findings demonstrate the presence of telocytes in the rat testicular interstitium. These cells interact with peritubular myoid cells, seminiferous tubules, Leydig cells and blood vessels via long telopode extensions, which suggests their vital role in the intercellular communication between different cell types within the rat testis.
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Registered trials
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