ArticleProceedings of the National Academy of Sciences of the United States of America2019
Motility-limited aggregation of mammary epithelial cells into fractal-like clusters.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Label-free all-electrical tracking of individual and collective cell migration on a megapixel CMOS capacitance sensor.Lab on a chip · 2026Article
- Label-Free All-Electrical Tracking of Individual and Collective Cell Migration on a Megapixel CMOS Capacitance Sensor.bioRxiv : the preprint server for biology · 2026Article
- A fractal pattern of hierarchical genetic population structure in mixed stocks across fish segregated by dams revealed by genomic resources for curimba Prochilodus lineatus.Journal of fish biology · 2026Article
- Global warming and obesity: External heat exposure as a modulator of energy balance.FASEB bioAdvances · 2025Review
- PIN2-mediated self-organizing transient auxin flow contributes to auxin maxima at the tip of Arabidopsis cotyledons.Nature communications · 2025Article
- Learning collective cell migratory dynamics from a static snapshot with graph neural networks.ArXiv · 2024Article
- PIN2-mediated self-organizing transient auxin flow contributes to auxin maxima at the tip of Arabidopsis cotyledons.bioRxiv : the preprint server for biology · 2024Article
- The Pathologically Evolving Aggregation-State of Cells in Cancerous Tissues as Interpreted by Fractal and Multi-Fractal Dispersion Theory in Saturated Porous Formations.Bioengineering (Basel, Switzerland) · 2024Article
- Cancer metabolism and carcinogenesis.Experimental hematology & oncology · 2024Review
- Bridging the gap between collective motility and epithelial-mesenchymal transitions through the active finite voronoi model.Soft matter · 2023Article
- Topological data analysis of spatial patterning in heterogeneous cell populations: clustering and sorting with varying cell-cell adhesion.NPJ systems biology and applications · 2023Article
- Fractal dimension to characterize interactions between blood and lymphatic endothelial cells.Physical biology · 2023Article
- Biophysical informatics reveals distinctive phenotypic signatures and functional diversity of single-cell lineages.Bioinformatics (Oxford, England) · 2023Article
- Soft Tissue Hybrid Model for Real-Time Simulations.Polymers · 2022Article
- PI3K-AKT, JAK2-STAT3 pathways and cell-cell contact regulate maspin subcellular localization.Cell communication and signaling : CCS · 2021Article
- Topological data analysis of collective and individual epithelial cells using persistent homology of loops.Soft matter · 2021Article
- The epithelial-mesenchymal transition and the cytoskeleton in bioengineered systems.Cell communication and signaling : CCS · 2021Review
- Mechanophenotyping of 3D multicellular clusters using displacement arrays of rendered tractions.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Unjamming and collective migration in MCF10A breast cancer cell lines.Biochemical and biophysical research communications · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Migratory cells transition between dispersed individuals and multicellular collectives during development, wound healing, and cancer. These transitions are associated with coordinated behaviors as well as arrested motility at high cell densities, but remain poorly understood at lower cell densities. Here, we show that dispersed mammary epithelial cells organize into arrested, fractal-like clusters at low density in reduced epidermal growth factor (EGF). These clusters exhibit a branched architecture with a fractal dimension of [Formula: see text], reminiscent of diffusion-limited aggregation of nonliving colloidal particles. First, cells display diminished motility in reduced EGF, which permits irreversible adhesion upon cell-cell contact. Subsequently, leader cells emerge that guide collectively migrating strands and connect clusters into space-filling networks. Thus, this living system exhibits gelation-like arrest at low cell densities, analogous to the glass-like arrest of epithelial monolayers at high cell densities. We quantitatively capture these behaviors with a jamming-like phase diagram based on local cell density and EGF. These individual to collective transitions represent an intriguing link between living and nonliving systems, with potential relevance for epithelial morphogenesis into branched architectures.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.