Evidence map›Paper›PMID 31413173›Full record

ArticlemSphere2019

Genetic Determinants of Virulence between Two Foot-and-Mouth Disease Virus Isolates Which Caused Outbreaks of Differing Severity.

Tatsuya Nishi, Kazuki Morioka, Nobuko Saito, Makoto Yamakawa, Toru Kanno, Katsuhiko Fukai

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSphere, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Tatsuya NishiExotic Disease Research Station, National Institute of Animal Health, National Agriculture and Food Research Organization, Tokyo, Japan.
Kazuki MoriokaExotic Disease Research Station, National Institute of Animal Health, National Agriculture and Food Research Organization, Tokyo, Japan.
Nobuko SaitoExotic Disease Research Station, National Institute of Animal Health, National Agriculture and Food Research Organization, Tokyo, Japan.
Makoto YamakawaExotic Disease Research Station, National Institute of Animal Health, National Agriculture and Food Research Organization, Tokyo, Japan.
Toru KannoExotic Disease Research Station, National Institute of Animal Health, National Agriculture and Food Research Organization, Tokyo, Japan.
Katsuhiko FukaiExotic Disease Research Station, National Institute of Animal Health, National Agriculture and Food Research Organization, Tokyo, Japan fukai@affrc.go.jp.
National Institute of Animal Health · JPNational Agriculture and Food Research Organization · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Individual foot-and-mouth disease virus (FMDV) strains reveal different degrees of infectivity and pathogenicity in host animals. The differences in severity among outbreaks might be ascribable to these differences in infectivity among FMDV strains. To investigate the molecular mechanisms underlying these differences, we estimated the infectivity of O/JPN/2000 and O/JPN/2010, which caused outbreaks of markedly different scales, in cell lines, Holstein cattle, and suckling mice. Viral growth of the two strains in cells was not remarkably different; however, O/JPN/2000 showed apparently low transmissibility in cattle. Mortality rates of suckling mice inoculated intraperitoneally with a 50% tissue culture infective dose (TCID

Indexed as

Disease OutbreaksAnimalsAnimals, SucklingCapsid ProteinsCattleCell LineFoot-and-Mouth DiseaseFoot-and-Mouth Disease VirusMiceRNA, ViralVirulenceVirulence FactorsCapsid ProteinsRNA, ViralVirulence FactorsVP1 protein, Foot-and-mouth disease virusfoot-and-mouth disease virusgenetic determinantsvirulence

Identifiers

PMID31413173
PMCPMC6695517
OpenAlexW2968461876

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.