ArticleScience translational medicine2019
The
Open access · greenAbstract read
In one paragraph
Article in Science translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 189 papers, 9 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
189citing papers in PubMed, 9 pooled it
11.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
189 citing papers in PubMed, 9 syntheses or guidelines pooled it, 279 citations in OpenAlex.
- GWAS meta-analysis of cerebrospinal fluid Alzheimer's biomarkers reveals loci regulating lipids, brain volume and autophagy.Nature communications · 2026Pooled it
- Systematic Review on Neurotoxic Implications of Lead-Induced Gene Expression Alterations in the Etiology of Alzheimer's Disease.Cellular and molecular neurobiology · 2025Pooled it
- Pooled it
- Harmonization of CSF and imaging biomarkers in Alzheimer's disease: Need and practical applications for genetics studies and preclinical classification.Neurobiology of disease · 2024Pooled it
- Association of soluble TREM2 with Alzheimer's disease and mild cognitive impairment: a systematic review and meta-analysis.Frontiers in aging neuroscience · 2024Pooled it
- Causal effect of thyroid cancer on secondary primary malignancies: findings from the UK Biobank and FinnGen cohorts.Frontiers in immunology · 2024Pooled it
- Multi-ancestry meta-analysis and fine-mapping in Alzheimer's disease.Molecular psychiatry · 2023Pooled it
- Mendelian randomization and genetic colocalization infer the effects of the multi-tissue proteome on 211 complex disease-related phenotypes.Genome medicine · 2022Pooled it
- Genetic analysis of the human microglial transcriptome across brain regions, aging and disease pathologies.Nature genetics · 2022Pooled it
- Glial and Vascular Plasma Biomarkers Across the Alzheimer's Disease Continuum: An ADNI-Based Longitudinal Study.FASEB bioAdvances · 2026Article
- Plasticity of human microglia and brain perivascular macrophages in aging and Alzheimer's disease.Nature genetics · 2026Article
- Human TDP-43 expression worsens FTD-related phenotypes in progranulin-insufficient mice.Neurobiology of disease · 2026Article
- TREM2 in neurodegenerative diseases and acute neurological injuries: mechanisms to targeted therapies.Cell communication and signaling : CCS · 2026Review
- Retinal Transcriptome-Wide Association Study Identifies Novel Alzheimer's Disease Risk Genes.medRxiv : the preprint server for health sciences · 2026Article
- Functionally informed cis and trans proteome-wide association studies prioritize disease-critical genes.Research square · 2026Article
- Functionally informed cis and trans proteome-wide association studies prioritize disease-critical genes.medRxiv : the preprint server for health sciences · 2026Article
- APOE-stratified Proteomic and Metabolomic Analysis Reveals Mitochondrial Dysfunction Inflammation and Lipid Dysregulation in Alzheimer's Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- scTWAS: a powerful statistical framework for single-cell transcriptome-wide association studies.Nature communications · 2026Article
- Immune dysfunction in Alzheimer disease.Nature reviews. Neuroscience · 2026Review
- Interpretable integration of unpaired multi-omics for Alzheimer's diagnosis via cross-modal transformer reconstruction.PLoS computational biology · 2026Article
129 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
36 authors at 14 institutions in 6 countries.
Yuetiva DemingDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0001-7512-5703
Fabia FilipelloDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-7752-0974
Francesca CignarellaDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0003-0342-5699
Claudia CantoniDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0003-1868-4511
Simon HsuDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
Robert MikesellDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-1648-8288
Zeran LiDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-7434-6499
Jorge L Del-AguilaDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-6364-8707
Umber DubeDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0001-9324-1927
Fabiana Geraldo FariasDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-5215-7304
Joseph BradleyDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0003-0217-4808
John BuddeDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0001-7778-7276
Laura IbanezDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0003-2381-7059
Maria Victoria FernandezDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-9669-5147
Kaj BlennowDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.ORCID 0000-0002-1890-4193
Henrik ZetterbergDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Amanda HeslegraveDepartment of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK.ORCID 0000-0002-7290-6405
Per M JohanssonDepartment of Clinical Sciences Helsingborg, Lund University, Lund, Sweden.ORCID 0000-0003-0073-7654
Johan SvenssonDepartment of Internal Medicine, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Göteborg, Sweden.ORCID 0000-0002-4487-6405
Bengt NellgårdDepartment of Anesthesiology, Sahlgrenska University Hospital, Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Göteborg, Sweden.ORCID 0000-0003-2765-826X
Alberto LleoDepartment of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
Daniel AlcoleaDepartment of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.ORCID 0000-0002-3819-3245
Jordi ClarimonDepartment of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.ORCID 0000-0002-6824-6942
Lorena RamiIDIBAPS, Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Service, ICN Hospital Clinic, Barcelona, Spain.
José Luis MolinuevoIDIBAPS, Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Service, ICN Hospital Clinic, Barcelona, Spain.
Marc Suárez-CalvetBarcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain.ORCID 0000-0002-2993-569X
Estrella Morenas-RodríguezBiomedical Center (BMC), Biochemistry, Ludwig-Maximilians-Universität München, Munich, Germany.
Gernot KleinbergerBiomedical Center (BMC), Biochemistry, Ludwig-Maximilians-Universität München, Munich, Germany.
Michael EwersInstitute for Stroke and Dementia Research, University Hospital, LMU, Munich, Germany.ORCID 0000-0001-5231-1714
Oscar HarariDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-2635-6975
Christian HaassGerman Center for Neurodegenerative Diseases (DZNE), Munich, Germany.ORCID 0000-0002-4869-1627
Thomas J BrettHope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA.
Bruno A BenitezDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-2699-3878
Celeste M KarchDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA. karchc@wustl.edu picciol@wustl.edu ccruchaga@wustl.edu.ORCID 0000-0002-6854-5547
Laura PiccioDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA. karchc@wustl.edu picciol@wustl.edu ccruchaga@wustl.edu.
Carlos CruchagaDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA. karchc@wustl.edu picciol@wustl.edu ccruchaga@wustl.edu.ORCID 0000-0002-0276-2899
Washington University in St. Louis · USSahlgrenska University Hospital · SEUniversitat Autònoma de Barcelona · ESGerman Center for Neurodegenerative Diseases · DEBioscience Research · USHospital Clínic de Barcelona · ESLudwig-Maximilians-Universität München · DELund University · SEMunich Cluster for Systems Neurology · DEPasqual Maragall Foundation · ESThe University of Sydney · AUUK Dementia Research Institute · GBUniversity of Gothenburg · SEUniversity of Wisconsin–Madison · US
Funding
Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0MVascular Structure and Function in Cognitive AgingP01AG003949 · NIA · YESHIVA UNIVERSITY · PI CAROL A. DERBY · 1985 to 2026
$73.9MSmartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI JOHN MORRIS · 1985 to 2026
$69.5MImaging CoreU19AG032438 · NIA · WASHINGTON UNIVERSITY · PI BATEMAN, RANDALL J · 2010 to 2025
$53.9MWASHINGTON UNIVERSITY ALZHEIMERS DISEASE RESEARCH CENTERP50AG005681 · NIA · WASHINGTON UNIVERSITY · PI FAGAN, ANNE · 1985 to 2019
$52.1MSUPPLEMENT TO ALZHEIMERS DISEASE PATIENT REGISTRYU01AG006786 · NIA · MAYO CLINIC ROCHESTER · PI GRAFF-RADFORD, JONATHAN, JACK, CLIFFORD R. · 1986 to 2023
$49.6MThe natural history of AB accumulation in preclinical ADP01AG026276 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 2005 to 2025
$49.5MTHE PGRN/TDP-43 AXIS IN ALZHEIMER?S DISEASE AND NEURODEGENERATIONP50AG016574 · NIA · MAYO CLINIC ROCHESTER · PI PETERSEN, RONALD C · 1999 to 2018
$36.9MResearch Education ComponentP30AG019610 · NIA · SUN HEALTH RESEARCH INSTITUTE · PI REIMAN, ERIC MICHAEL · 2001 to 2020
$32.5MIntegrating the exposome and methylome to inform brain molecular changes in ADRD across established diverse cohorts.U01AG046139 · NIA · UNIVERSITY OF FLORIDA · PI ERTEKIN-TANER, NILUFER, FUNK, CORY · 2013 to 2022
$24.6MDominantly Inherited Alzheimer NetworkUF1AG032438 · NIA · WASHINGTON UNIVERSITY · PI BATEMAN, RANDALL J · 2014 to 2017
$21.6MTRANSGENIC MODELING OF TAUOPATHYP01AG017216 · NIA · MAYO CLINIC JACKSONVILLE · PI DICKSON, DENNIS WILLIAM · 1999 to 2011
$12.0MNHLBI NIH HHS R01 HL119813NIA NIH HHS K01 AG046374NIA NIH HHS P01 AG003949NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG017216NIA NIH HHS P01 AG026276NIA NIH HHS P30 AG019610NIA NIH HHS P50 AG005681NIA NIH HHS P50 AG016574NIA NIH HHS P50 AG025711NIA NIH HHS R01 AG018023NIA NIH HHS R01 AG032990NIA NIH HHS R01 AG044546NIA NIH HHS R01 AG057777NIA NIH HHS R01 AG058501NIA NIH HHS RF1 AG044546NIA NIH HHS RF1 AG053303NIA NIH HHS RF1 AG058501NIA NIH HHS T32 AG000213NIA NIH HHS U01 AG006786NIA NIH HHS U01 AG024904NIA NIH HHS U01 AG046139NIA NIH HHS U01 AG058922NIA NIH HHS U19 AG032438NIA NIH HHS UF1 AG032438NINDS NIH HHS R01 NS080820NINDS NIH HHS U24 NS072026
Abstract
Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) in cerebrospinal fluid (CSF) has been associated with Alzheimer's disease (AD). TREM2 plays a critical role in microglial activation, survival, and phagocytosis; however, the pathophysiological role of sTREM2 in AD is not well understood. Understanding the role of sTREM2 in AD may reveal new pathological mechanisms and lead to the identification of therapeutic targets. We performed a genome-wide association study (GWAS) to identify genetic modifiers of CSF sTREM2 obtained from the Alzheimer's Disease Neuroimaging Initiative. Common variants in the membrane-spanning 4-domains subfamily A (
Indexed as
Alzheimer DiseaseFemaleGenome-Wide Association StudyHumansMacrophagesMaleMembrane GlycoproteinsMembrane ProteinsMeta-Analysis as TopicMultigene FamilyReceptors, ImmunologicMembrane GlycoproteinsMembrane ProteinsMS4A4A protein, humanReceptors, ImmunologicTREM2 protein, human
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.