ArticleThe Journal of experimental medicine2019
Risk of Zika microcephaly correlates with features of maternal antibodies.
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Article in The Journal of experimental medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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45citing papers in PubMed
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Who cites it
45 citing papers in PubMed, 53 citations in OpenAlex.
- A Zika virus vaccine with E protein fusion loop mutations protects via CD8Nature microbiology · 2026Article
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- Human antibodies against West Nile and related orthoflaviviruses.bioRxiv : the preprint server for biology · 2026Article
- A systematic review and meta-analysis of Zika virus epidemiology.Nature health · 2026Article
- Development of Maternal Antibodies Post ZIKV in Pregnancy is Associated with Lower Risk of Microcephaly and Structural Brain Abnormalities in Exposed Infants.The Journal of infectious diseases · 2025Article
- Maternal Antibodies to Neurovirulent Pathogens in Fetal Tissues.Annual review of virology · 2025Review
- Modeling Virus-Associated Central Nervous System Disease in Non-Human Primates.International journal of molecular sciences · 2025Review
- Role of non-human primate models in accelerating research and developing countermeasures against Zika virus infection.The Lancet. Microbe · 2025Review
- Review
- Low Antibody-Dependent Enhancement of Viral Entry Activity Supports the Safety of Inactivated SARS-CoV-2 Vaccines.Vaccines · 2025Article
- Anti-S2 antibodies responsible for the SARS-CoV-2 infection-induced serological cross-reactivity against MERS-CoV and MERS-related coronaviruses.Frontiers in immunology · 2025Article
- Fc-FcγR interactions during infections: From neutralizing antibodies to antibody-dependent enhancement.Immunological reviews · 2024Review
- Emerging and reemerging infectious diseases: global trends and new strategies for their prevention and control.Signal transduction and targeted therapy · 2024Review
- Mouse models of Zika virus transplacental transmission.Antiviral research · 2023Review
- Control of maternal Zika virus infection during pregnancy is associated with lower antibody titers in a macaque model.Frontiers in immunology · 2023Article
- Adaptation to host cell environment during experimental evolution of Zika virus.Communications biology · 2022Article
- Effect of prior Zika and dengue virus exposure on the severity of a subsequent dengue infection in adults.Scientific reports · 2022Article
- Microcephaly and Associated Risk Factors in Newborns: A Systematic Review and Meta-Analysis Study.Tropical medicine and infectious disease · 2022Review
- Zika virus-like particle vaccine fusion loop mutation increases production yield but fails to protect AG129 mice against Zika virus challenge.PLoS neglected tropical diseases · 2022Article
- Measles-based Zika vaccine induces long-term immunity and requires NS1 antibodies to protect the female reproductive tract.NPJ vaccines · 2022Article
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Authors and funding
60 authors at 17 institutions in 3 countries.
Davide F Robbiani *Laboratory of Molecular Immunology, The Rockefeller University, New York, NY drobbiani@rockefeller.edu.ORCID 0000-0001-7379-3484
Priscilla C Olsen *Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
Federico Costa *Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT.
Qiao Wang *Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.ORCID 0000-0001-6416-1733
Thiago Y Oliveira *Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
Nivison NeryInstituto Gonçalo Moniz, Fundação Oswaldo Cruz/MS, Salvador, Bahia, Brazil.
Adeolu AromolaranDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT.
Mateus S do RosárioHospital Geral Roberto Santos, Secretária da Saúde do Estado da Bahia, Salvador, Brazil.
Gielson A SacramentoInstituto Gonçalo Moniz, Fundação Oswaldo Cruz/MS, Salvador, Bahia, Brazil.
Jaqueline S CruzInstituto Gonçalo Moniz, Fundação Oswaldo Cruz/MS, Salvador, Bahia, Brazil.
Ricardo KhouriInstituto Gonçalo Moniz, Fundação Oswaldo Cruz/MS, Salvador, Bahia, Brazil.
Elsio A WunderDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT.ORCID 0000-0002-5239-8511
Adriana MattosHospital Geral Roberto Santos, Secretária da Saúde do Estado da Bahia, Salvador, Brazil.
Bruno de Paula FreitasHospital Geral Roberto Santos, Secretária da Saúde do Estado da Bahia, Salvador, Brazil.
Manoel SarnoFaculdade de Medicina and Instituto da Saúde Coletiva, Universidade Federal da Bahia, Salvador, Bahia, Brazil.
Gracinda ArchanjoHospital Geral Roberto Santos, Secretária da Saúde do Estado da Bahia, Salvador, Brazil.
Dina DaltroHospital Geral Roberto Santos, Secretária da Saúde do Estado da Bahia, Salvador, Brazil.
Gustavo B S CarvalhoHospital Geral Roberto Santos, Secretária da Saúde do Estado da Bahia, Salvador, Brazil.
Kleber PimentelHospital Geral Roberto Santos, Secretária da Saúde do Estado da Bahia, Salvador, Brazil.
Isadora C de SiqueiraInstituto Gonçalo Moniz, Fundação Oswaldo Cruz/MS, Salvador, Bahia, Brazil.ORCID 0000-0002-2520-4099
João R M de AlmeidaFaculdade de Medicina and Instituto da Saúde Coletiva, Universidade Federal da Bahia, Salvador, Bahia, Brazil.ORCID 0000-0002-2747-7218
Daniele F HenriquesInstituto Evandro Chagas, Ministério da Saúde Ananindeua, Pará, Brazil.
Juliana A LimaInstituto Evandro Chagas, Ministério da Saúde Ananindeua, Pará, Brazil.
Pedro F C VasconcelosInstituto Evandro Chagas, Ministério da Saúde Ananindeua, Pará, Brazil.
Dennis Schaefer-BabajewLaboratory of Molecular Immunology, The Rockefeller University, New York, NY.
Stephanie A AzzopardiLaboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY.
Leonia BozzaccoLaboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY.
Anna GazumyanLaboratory of Molecular Immunology, The Rockefeller University, New York, NY.
Rubens BelfortUniversidade Federal de São Paulo, São Paulo, Brazil.ORCID 0000-0002-8422-3898
Ana P AlcântaraHospital Santo Amaro, Salvador, Bahia, Brazil.
Gustavo CarvalhoHospital Santo Amaro, Salvador, Bahia, Brazil.
Licia MoreiraHospital Santo Amaro, Salvador, Bahia, Brazil.ORCID 0000-0001-5009-8577
Katiaci AraujoHospital Aliança, Salvador, Bahia, Brazil.
Mitermayer G ReisInstituto Gonçalo Moniz, Fundação Oswaldo Cruz/MS, Salvador, Bahia, Brazil.
Rebekah I KeeslerCalifornia National Primate Research Center, University of California, Davis, Davis, CA.
Lark L CoffeyDepartment of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, Davis, CA.
Jennifer Tisoncik-GoWashington National Primate Research Center, Seattle, WA.
Michael GaleWashington National Primate Research Center, Seattle, WA.ORCID 0000-0002-6332-7436
Lakshmi RajagopalDepartment of Global Health, University of Washington, Seattle, WA.
Kristina M Adams WaldorfWashington National Primate Research Center, Seattle, WA.
Dawn M DudleyDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI.ORCID 0000-0003-0934-2042
Heather A SimmonsWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI.
Andres MejiaWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI.ORCID 0000-0001-6088-3595
David H O'ConnorDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI.
Rosemary J SteinbachDivision of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Beaverton, OR.
Nicole HaeseDivision of Pathobiology and Immunology, Oregon National Primate Research Center, Beaverton, OR.ORCID 0000-0003-4871-2763
Jessica SmithVaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, OR.
Anne LewisPathology Services Unit, Division of Comparative Medicine, Oregon National Primate Research Center, Beaverton, OR.ORCID 0000-0003-4059-7318
Lois ColginDivision of Pathobiology and Immunology, Oregon National Primate Research Center, Beaverton, OR.
Victoria RobertsDivision of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Beaverton, OR.
Antonio FriasDivision of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Beaverton, OR.
Meredith KelleherDivision of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Beaverton, OR.ORCID 0000-0002-5313-004X
Alec HirschDivision of Pathobiology and Immunology, Oregon National Primate Research Center, Beaverton, OR.
Daniel N StreblowDivision of Pathobiology and Immunology, Oregon National Primate Research Center, Beaverton, OR.
Charles M RiceLaboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY.
Margaret R MacDonaldLaboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY.ORCID 0000-0001-5177-2068
Antonio R P de AlmeidaFaculdade de Medicina and Instituto da Saúde Coletiva, Universidade Federal da Bahia, Salvador, Bahia, Brazil.
Koen K A Van Rompay *California National Primate Research Center, University of California, Davis, Davis, CA.ORCID 0000-0002-7375-1337
Albert I Ko *Instituto Gonçalo Moniz, Fundação Oswaldo Cruz/MS, Salvador, Bahia, Brazil.ORCID 0000-0001-9023-2339
Michel C Nussenzweig *Laboratory of Molecular Immunology, The Rockefeller University, New York, NY nussen@rockefeller.edu.ORCID 0000-0003-0592-8564
Oregon National Primate Research Center · USHospital São Rafael · BRRockefeller University · USFundação Oswaldo Cruz · BRUniversidade Federal da Bahia · BRUniversity of Wisconsin–Madison · USMinistério da Saúde · BRUniversity of California, Davis · USUniversity of Washington · USYale University · USHospital Ana Nery · BRHoward Hughes Medical Institute · USInfectious Disease Research Institute · USOregon Health & Science University · USShanghai Medical College of Fudan University · CNUniversidade Federal de São Paulo · BRUniversidade Federal do Rio de Janeiro · BR
Funding
Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9MWashington National Primate Research CenterP51OD010425 · OD · UNIVERSITY OF WASHINGTON · PI Mari Ostendorf · 2012 to 2026
$201.8MNational Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5MWNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7MSupport Component D/Vaccine Discovery, Concept to ClinicUM1AI100663 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI MCELRATH, MARGARET JULIANA · 2012 to 2018
$131.5MUsing a tonsil organoid system to probe conditions for the induction of protective antibody and T cell responses to influenza.U19AI057229 · NIAID · STANFORD UNIVERSITY · PI Mark Morris Davis · 2003 to 2026
$88.5MDeveloping, Demonstrating, and Disseminating Innovative Programs to Achieve Translational SuccessUL1TR001866 · NCATS · ROCKEFELLER UNIVERSITY · PI COLLER, BARRY, KRUEGER, JAMES G · 2016 to 2025
$40.6MUnderstanding B cell memory in response to diverse virus infectionsU19AI111825 · NIAID · ROCKEFELLER UNIVERSITY · PI RAVETCH, JEFFREY VICTOR · 2014 to 2023
$26.0MWest Nile Virus and host control of innate defensesU19AI083019 · NIAID · UNIVERSITY OF WASHINGTON · PI CLARK, EDWARD A · 2009 to 2018
$22.5MVirology CoreP01AI138938 · NIAID · ROCKEFELLER UNIVERSITY · PI RICE, CHARLES M · 2018 to 2022
$8.4MUnraveling yellow fever 17D vaccine attenuation: The role of type I interferon and innate immunityR01AI124690 · NIAID · ROCKEFELLER UNIVERSITY · PI Charles M Rice · 2016 to 2026
$8.3MNaturally-Acquired and Vaccine-Mediated Immunity to LeptospirosisR01AI121207 · NIAID · YALE UNIVERSITY · PI KO, ALBERT ICKSANG, REIS, MITERMAYER GALVAO DOS · 2016 to 2020
$6.4MFIC NIH HHS R01 TW009504FIC NIH HHS R25 TW009338NCATS NIH HHS UL1 TR001866NCRR NIH HHS C06 RR015459NCRR NIH HHS C06 RR020141NIAID NIH HHS P01 AI138938NIAID NIH HHS R01 AI037526NIAID NIH HHS R01 AI100989NIAID NIH HHS R01 AI104002NIAID NIH HHS R01 AI121207NIAID NIH HHS R01 AI124690NIAID NIH HHS R01 AI133976NIAID NIH HHS R21 AI129479NIAID NIH HHS U19 AI057229NIAID NIH HHS U19 AI083019NIAID NIH HHS U19 AI111825NIAID NIH HHS UM1 AI100663NICHD NIH HHS R21 HD091032NIH HHS P51 OD010425NIH HHS P51 OD011092NIH HHS P51 OD011106NIH HHS P51 OD011107Wellcome Trust
Abstract
Zika virus (ZIKV) infection during pregnancy causes congenital abnormalities, including microcephaly. However, rates vary widely, and the contributing risk factors remain unclear. We examined the serum antibody response to ZIKV and other flaviviruses in Brazilian women giving birth during the 2015-2016 outbreak. Infected pregnancies with intermediate or higher ZIKV antibody enhancement titers were at increased risk to give birth to microcephalic infants compared with those with lower titers (P < 0.0001). Similarly, analysis of ZIKV-infected pregnant macaques revealed that fetal brain damage was more frequent in mothers with higher enhancement titers. Thus, features of the maternal antibodies are associated with and may contribute to the genesis of ZIKV-associated microcephaly.
Indexed as
AnimalsAntibodies, ViralBrainFemaleFetusHumansK562 CellsMacaca mulattaMacaca nemestrinaMaternal-Fetal ExchangeMicrocephalyPregnancyPregnancy Complications, InfectiousZika VirusZika Virus InfectionAntibodies, Viral
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