Evidence map›Paper›PMID 31412979›Full record

ArticleUltrasound in medicine & biology2019

Pulmonary Capillary Hemorrhage Induced by Super Sonic Shear Wave Elastography in Rats.

Douglas L Miller, Zhihong Dong, Chunyan Dou, Brandon Patterson, Krishnan Raghavendran

Open access · greenAbstract read
In one paragraph

Article in Ultrasound in medicine & biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Lung Ultrasound Elastography: New Tools to Personalize Mechanical Ventilation.American journal of respiratory and critical care medicine · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. New International Guidelines and Consensus on the Use of Lung Ultrasound.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2023
    Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Douglas L MillerDepartment of Radiology, University of Michigan, Ann Arbor, Michigan, USA. Electronic address: douglm@umich.edu.
Zhihong DongDepartment of Radiology, University of Michigan, Ann Arbor, Michigan, USA.
Chunyan DouDepartment of Radiology, University of Michigan, Ann Arbor, Michigan, USA.
Brandon PattersonDepartment of Radiology, University of Michigan, Ann Arbor, Michigan, USA.
Krishnan RaghavendranDepartment of Surgery, University of Michigan, Ann Arbor, Michigan, USA.
University of Michigan–Ann Arbor · US

Funding

Ultrasound-Induced Pulmonary Hemorrhage During Diagnostic Examination of the LungR01HL116434 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MILLER, DOUGLAS LAWRENCE · 2013 to 2021
$4.2M
NHLBI NIH HHS R01 HL116434
6 · The paper itself

Abstract

The occurrence of the pulmonary capillary hemorrhage (PCH) bioeffect of diagnostic ultrasound in rats was investigated for a SuperSonic Imagine shear wave elastography system (Aixplorer, Supersonic Imagine, Aix-en-Provence, France). The elastography imaging repeated at 1 Hz and consisted of widely spaced B-mode image pulses, supersonic push (SSP) pulses and shear wave imaging (SWI) pulses. Groups of rats anesthetized with ketamine and xylazine, or with ketamine only, were imaged on their right side in a warm water bath for one frame, 30 s and 300 s. The image focus and region of interest were adjusted to give exposure only with the background B-mode imaging, or primarily with the SSP and SWI pulses. A sham group had only low power aiming scans. The lungs were removed 5 min after exposure and evaluated for PCH area and volume. The B mode was notably ineffective and produced significant PCH only at the maximum 0 dB output. The SSP pulses together with the SWI pulses produced significant PCH for 300 s, 30 s and even single image exposures. Peak rarefactional pressure amplitude PCH thresholds for 300 s exposure were the same with or without the B-mode pulses at 1.5 MPa (in situ mechanical index, MI

Indexed as

AnimalsCapillariesElasticity Imaging TechniquesFemaleHemorrhageLungLung DiseasesRatsRats, Sprague-DawleyComet tail artifactDiagnostic ultrasound safetyMechanical indexPulmonary diagnostic ultrasoundUltrasound elastography

Identifiers

PMID31412979
PMCPMC6768750
OpenAlexW2968591853

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.