Trial reportJournal of orthopaedic surgery and research2019
Oral administration of Lactobacillus casei Shirota improves recovery of hand functions after distal radius fracture among elder patients: a placebo-controlled, double-blind, and randomized trial.
Trial report in Journal of orthopaedic surgery and research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- Emerging Roles of the Gut Microbiome in Musculoskeletal Injury and Repair.Microorganisms · 2025Review
- Opportunities and challenges of bacterial extracellular vesicles in regenerative medicine.Journal of nanobiotechnology · 2025Review
- Current Management and Volar Locking Plate Fixation with Bone Cement Augmentation for Elderly Distal Radius Fractures-An Updated Narrative Review.Journal of clinical medicine · 2023Review
- The Potential Value of Probiotics after Dental Implant Placement.Microorganisms · 2023Review
- Bifidobacterium longum supplementation improves age-related delays in fracture repair.Aging cell · 2023Article
- Probiotics: Can it modulate fracture healing?PloS one · 2023Article
- Probiotic supplementation attenuates age-related sarcopenia via the gut-muscle axis in SAMP8 mice.Journal of cachexia, sarcopenia and muscle · 2022Article
- Probiotics for the Prevention of Acute Respiratory-Tract Infections in Older People: Systematic Review.Healthcare (Basel, Switzerland) · 2021Review
- Bifidobacterium adolescentis supplementation attenuates fracture-induced systemic sequelae.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundTo evaluate the effect of oral Lactobacillus casei Shirota (LcS) administration on recovery of hand functions in senior patients diagnosed with an acute distal radius fracture.
methodsThis clinical trial is double-blind and placebo-controlled, in which 293 senior patients with distal radius fracture were initially enrolled. After exclusion, 264 eligible patients were randomly assigned to receive oral placebo or LcS daily for a period of 3 months after the fracture. Treatment outcomes were Michigan Hand Questionnaire (MHQ) score, radial deviation and inclination, and ulnar deviation and variance, all of which were monitored and measured every month.
resultsThroughout the length of this study, MHQ score, radial deviation and inclination, and ulnar deviation and variance of patients on oral LcS displayed a significantly faster improvement in comparison to those receiving placebo, over the 3-month intervention period.
conclusionOral administration of LcS dramatically accelerated hand function recovery in senior patients with distal radius fracture.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.