ArticleBMC complementary and alternative medicine2019
Pharmacological properties of Centella asiatica hydrogel in accelerating wound healing in rabbits.
Article in BMC complementary and alternative medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.
- A Systematic Review of the Effect ofInternational journal of environmental research and public health · 2022Pooled it
- Transfersomal delivery ofDrug delivery · 2025Article
- Strategies for Incorporating Natural Therapeutic Agents into Hydrogel Dressings: Innovations in Wound Healing.Polymers · 2025Review
- Comparative Analysis of Animal Models in Wound Healing Research and the Utility for Humanized Mice Models.Advances in wound care · 2025Review
- Development of 3D-Printed Hydrogel Disks as Standardized Platform for Evaluating Excipient Impact on Metronidazole's Antimicrobial Activity.Pharmaceutics · 2025Article
- Development and Application of a Novel 'Green' Antibacterial Black Garlic (Food technology and biotechnology · 2025Article
- Review
- Promotion of chronic wound healing by plant-derived active ingredients and research progress and potential of plant polysaccharide hydrogels.Chinese herbal medicines · 2025Review
- Ethnomedical Knowledge of Plants Used in Nonconventional Medicine for Wound Healing in Lubumbashi, Haut-Katanga Province, DR Congo.TheScientificWorldJournal · 2024Article
- Chitosan-Based Hydrogels for Controlled Delivery of Asiaticoside-RichInternational journal of molecular sciences · 2023Article
- Plant Extracts as Skin Care and Therapeutic Agents.International journal of molecular sciences · 2023Review
- Development of Natural Active Agent-Containing Porous Hydrogel Sheets with High Water Content for Wound Dressings.Gels (Basel, Switzerland) · 2023Article
- Asiaticoside Increases Caspase-9 Activity in MCF-7 Cells and Inhibits TNF-α and IL-6 Expression in Nude Mouse Xenografts via the NF-κB Pathway.Molecules (Basel, Switzerland) · 2023Article
- Review
- Article
- A Comprehensive Review of Natural Compounds for Wound Healing: Targeting Bioactivity Perspective.International journal of molecular sciences · 2022Review
- Article
- Advancements in Skin Delivery of Natural Bioactive Products for Wound Management: A Brief Review of Two Decades.Pharmaceutics · 2022Review
- Preparation and Safety Evaluation ofEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Green extraction optimization of triterpenoid glycoside-enriched extract from Centella asiatica (L.) Urban using response surface methodology (RSM).Scientific reports · 2021Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundVarious extracts of Centella asiatica (Apiaceae) and its active constituent, asiaticoside, have been reported to possess wound healing property when assessed using various in vivo and in vitro models. In an attempt to develop a formulation with accelerated wound healing effect, the present study was performed to examine in vivo efficacy of asiaticoside-rich hydrogel formulation in rabbits.
methodsAsiaticoside-rich fraction was prepared from C. asiatica aerial part and then incorporated into polyvinyl alcohol/polyethylene glycol (PVA/PEG) hydrogel. The hydrogel was subjected to wound healing investigation using the in vivo incision model.
resultsThe results obtained demonstrated that: i) the hydrogel formulation did not cause any signs of irritation on the rabbits' skin and; ii) enhanced wound healing 15% faster than the commercial cream and > 40% faster than the untreated wounds. The skin healing process was seen in all wounds marked by formation of a thick epithelial layer, keratin, and moderate formation of granulation tissues, fibroblasts and collagen with no fibrinoid necrosis detected.
conclusionThe asiaticoside-rich hydrogel developed using the freeze-thaw method was effective in accelerating wound healing in rabbits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.