Evidence map›Paper›PMID 31412752›Full record

SynthesisStroke2019

Sex Differences in Outcome After Endovascular Stroke Therapy for Acute Ischemic Stroke.

Sunil A Sheth, Songmi Lee, Steven J Warach, Jan Gralla, Reza Jahan, Mayank Goyal, Raul G Nogueira, Osama O Zaidat, Vitor M Pereira, Adnan Siddiqui and 4 more

Open access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Stroke, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 95 citations in OpenAlex.

  1. Article
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  4. Article
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  8. Review
  9. Observational
  10. Article
  11. Article
  12. Review
  13. COVID-19 and stroke in women: impact on clinical, psychosocial and research aspects.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Review
  14. Article
  15. Article
  16. Article
  17. Article
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  19. Article
  20. TREAT-AIS: A Multicenter National Registry.Stroke (Hoboken, N.J.) · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 10 institutions in 3 countries.

Sunil A ShethFrom the Department of Neurology, McGovern School of Medicine, University of Texas Health Science Center at Houston (S.A.S., S.L., L.D.M.).
Songmi LeeFrom the Department of Neurology, McGovern School of Medicine, University of Texas Health Science Center at Houston (S.A.S., S.L., L.D.M.).
Steven J WarachDepartment of Neurology, Dell School of Medicine, University of Texas at Austin (S.J.W.).
Jan GrallaDepartment of Neuroradiology, Inselspital, University Hospital, Berne, Switzerland (J.G.).
Reza JahanDepartment of Radiological Sciences, Ronald Reagan UCLA Medical Center, Santa Monica (R.J.).
Mayank GoyalDepartment of Radiology and Clinical Neurosciences, University of Calgary, AB, Canada (M.G.).
Raul G NogueiraDepartment of Neurology, Emory School of Medicine, Atlanta, GA (R.G.N.).
Osama O ZaidatDepartment of Neurosurgery, Mercy Health, Toledo, OH (O.O.Z.).
Vitor M PereiraDepartment of Medical Imaging, Toronto Western Hospital, ON, Canada (V.M.P.).
Adnan SiddiquiDepartment of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences, University of Buffalo, NY (A.S.).
Helmi LutsepDepartment of Neurology, Oregon Health and Science University, Portland (H.L.).
David S LiebeskindDepartment of Neurology, Ronald Reagan UCLA Medical Center, Santa Monica (D.S.L., J.L.S.).
Louise D McCulloughFrom the Department of Neurology, McGovern School of Medicine, University of Texas Health Science Center at Houston (S.A.S., S.L., L.D.M.).
Jeffrey L SaverDepartment of Neurology, Ronald Reagan UCLA Medical Center, Santa Monica (D.S.L., J.L.S.).
Ronald Reagan UCLA Medical Center · USThe University of Texas Health Science Center at Houston · USEmory and Henry College · USMercy Health · USOregon Health & Science University · USThe University of Texas at Austin · USToronto Western Hospital · CAUniversity at Buffalo, State University of New York · USUniversity Hospital of Bern · CHUniversity of Calgary · CA

Funding

Pyschosocial Stress and the Response to StrokeR37NS096493 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MCCULLOUGH, LOUISE D. · 2016 to 2022
$5.2M
Gender Differences in Ischemic Cell DeathR01NS055215 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MCCULLOUGH, LOUISE D. · 2007 to 2016
$4.3M
Psychosocial Stress and Behavioral Response to StrokeR01NS077769 · NINDS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI MCCULLOUGH, LOUISE D. · 2011 to 2014
$2.3M
NINDS NIH HHS R01 NS055215NINDS NIH HHS R01 NS077769NINDS NIH HHS R37 NS096493
6 · The paper itself

Abstract

Background and Purpose- We determined the effect of sex on outcome after endovascular stroke thrombectomy in acute ischemic stroke, including lifelong disability outcomes. Methods- We analyzed patients treated with the Solitaire stent retriever in the combined SWIFT (Solitaire FR With the Intention for Thrombectomy), STAR (Solitaire FR Thrombectomy for Acute Revascularization), and SWIFT PRIME (Solitaire FR With the Intention for Thrombectomy as Primary Endovascular Treatment) cohorts. Ordinal and logistic regression were used to examine known factors influencing outcome after endovascular stroke thrombectomy and study the effect of sex on the association between these factors and outcomes, including age and time to reperfusion. Years of optimal life after thrombectomy were defined as disability-adjusted life years and calculated by projecting disability through adjusted poststroke life expectancy by sex. Results- Among 389 patients treated with endovascular stroke thrombectomy, 55% were females, and median National Institutes of Health Stroke Scale was 17 (interquartile range, 8-28). There were no differences between females versus males in presenting deficit severity (National Institutes of Health Stroke Scale score, 17 versus 17, P=0.21), occlusion location (69% versus 64% M1, P=0.62), presenting infarct extent (Alberta Stroke Program Early CT Score 8 versus 8, P=0.24), rate of substantial reperfusion (Thrombolysis in Cerebral Infarction 2b/3, 87% versus 83%, P=0.37), onset to reperfusion time (294 versus 302 minutes, P=0.46). Despite older ages (69 versus 64, P<0.001) and higher rate of atrial fibrillation (45% versus 30%, P=0.002) for females compared with males, adjusted rates of functional independence at 90 days were similar (odds ratio, 1.0; 95% CI, 0.6-1.6). After adjusting for age at presentation and stroke severity, females had more years of optimal life (disability-adjusted life year) after endovascular stroke thrombectomy, 10.6 versus 8.5 years (P<0.001). Conclusions- Despite greater age and higher rate of atrial fibrillation, females experienced comparable functional outcomes and greater years of optimal life after intervention compared with males.

Indexed as

Sex CharacteristicsAgedAged, 80 and overBrain IschemiaEndovascular ProceduresFemaleHumansMaleMiddle AgedMulticenter Studies as TopicProspective StudiesRandomized Controlled Trials as TopicStrokeThrombectomyTreatment Outcomecerebrovascular strokelife expectancyreperfusionsexthrombectomy

Identifiers

PMID31412752
PMCPMC6710145
OpenAlexW2968402955

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.