Evidence map›Paper›PMID 31412725›Full record

ArticleCirculation2019

Nuclear

Palas K Chanda, Shu Meng, Jieun Lee, Honchiu E Leung, Kaifu Chen, John P Cooke

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Role of angiogenic transdifferentiation in vascular recovery.Frontiers in cardiovascular medicine · 2023
    Review
  13. Review
  14. Article
  15. The Role of Nitric Oxide in Stem Cell Biology.Antioxidants (Basel, Switzerland) · 2022
    Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Palas K ChandaCenter for Cardiovascular Regeneration, Department of Cardiovascular Sciences, Houston Methodist Research Institute, TX (P.K.C., S.M., K.C., J.P.C.).
Shu MengCenter for Cardiovascular Regeneration, Department of Cardiovascular Sciences, Houston Methodist Research Institute, TX (P.K.C., S.M., K.C., J.P.C.).
Jieun LeeAgeX Therapeutics Inc, Alameda, CA (J.L.).
Honchiu E LeungDepartment of Medicine, Baylor College of Medicine, Houston, TX (H.E.L.).
Kaifu ChenCenter for Cardiovascular Regeneration, Department of Cardiovascular Sciences, Houston Methodist Research Institute, TX (P.K.C., S.M., K.C., J.P.C.).
John P CookeCenter for Cardiovascular Regeneration, Department of Cardiovascular Sciences, Houston Methodist Research Institute, TX (P.K.C., S.M., K.C., J.P.C.).
Houston Methodist · USAlameda Hospital · USBaylor College of Medicine · US

Funding

Role of S-nitrosylation in TransdifferentiationR01HL133254 · NHLBI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI CHEN, KAIFU, COOKE, JOHN P · 2018 to 2021
$1.6M
Computational epigenetics modeling of cell identity genesR01GM125632 · NIGMS · METHODIST HOSPITAL RESEARCH INSTITUTE · PI CHEN, KAIFU · 2018 to 2021
$1.4M
NHLBI NIH HHS R01 HL133254NIGMS NIH HHS R01 GM125632
6 · The paper itself

Abstract

backgroundWe found that cell-autonomous innate immune signaling causes global changes in the expression of epigenetic modifiers to facilitate nuclear reprogramming to pluripotency. A role of

methodsWe used murine embryonic fibroblasts containing a doxycycline-inducible cassette encoding the Yamanaka factors (

resultsWe show that an optimal zone of innate immune activation, as defined by maximal yield of induced pluripotent stem cells, is determined by the degree of activation of nuclear factor κ-light-chain-enhancer of activated B cells; NO generation;

conclusionsThis is the first report showing that DNA accessibility and induced pluripotent stem cell yield depend on the extent of cell-autonomous innate immune activation and NO generation. This "Goldilocks zone" for inflammatory signaling and epigenetic plasticity may have broader implications for cell fate and phenotypic fluidity.

Indexed as

AnimalsCell DifferentiationCellular ReprogrammingEpigenesis, GeneticFibroblastsHumansImmunity, InnateInduced Pluripotent Stem CellsKruppel-Like Factor 4MiceMice, KnockoutNeoplasm ProteinsNitric Oxide SynthaseNitric Oxide Synthase Type IINitrogen OxidesSignal TransductionKLF4 protein, humanKlf4 protein, mouseKruppel-Like Factor 4Mta3 protein, mouseNeoplasm ProteinsNitric Oxide SynthaseNitric Oxide Synthase Type IINitrogen OxidesNos2 protein, mousecellular reprogrammingchromatinepigenomicsimmunity, innateinduced pluripotent stem cellsinflammationnitric oxide

Identifiers

PMID31412725
PMCPMC6951243
OpenAlexW2968135288

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.