Evidence map›Paper›PMID 31412678›Full record

ReviewCells2019

Mesenchymal Stem Cells for Regenerative Medicine.

Yu Han, Xuezhou Li, Yanbo Zhang, Yuping Han, Fei Chang, Jianxun Ding

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 570 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
570citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

570 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  18. Unraveling the Potential ofBiomacromolecules · 2026
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510 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yu HanDepartment of Orthopedics, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, China.
Xuezhou LiDepartment of Orthopedics, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, China.
Yanbo ZhangDepartment of Orthopedics, China-Japan Union Hospital of Jilin University, 126 Xiantai Street, Changchun 130033, China. zhangyb2012@jlu.edu.cn.ORCID 0000-0002-0729-3032
Yuping HanDepartment of Urology, China-Japan Union Hospital of Jilin University, 126 Xiantai Street, Changchun 130033, China. hyp181818@126.com.
Fei ChangDepartment of Orthopedics, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, China. ccfei_cn@hotmail.com.
Jianxun DingKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, China.ORCID 0000-0002-5232-8863

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent decades, the biomedical applications of mesenchymal stem cells (MSCs) have attracted increasing attention. MSCs are easily extracted from the bone marrow, fat, and synovium, and differentiate into various cell lineages according to the requirements of specific biomedical applications. As MSCs do not express significant histocompatibility complexes and immune stimulating molecules, they are not detected by immune surveillance and do not lead to graft rejection after transplantation. These properties make them competent biomedical candidates, especially in tissue engineering. We present a brief overview of MSC extraction methods and subsequent potential for differentiation, and a comprehensive overview of their preclinical and clinical applications in regenerative medicine, and discuss future challenges.

Indexed as

Cell DifferentiationRegenerative MedicineAnimalsHumansMesenchymal Stem CellsMesenchymal Stem Cell TransplantationTissue Engineeringbiomedical applicationcell differentiationextractionmesenchymal stem cell

Identifiers

PMID31412678
PMCPMC6721852

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.