ArticleBiomolecules2019
Wood-Based Cellulose Nanofibrils: Haemocompatibility and Impact on the Development and Behaviour of
Article in Biomolecules, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 44 citations in OpenAlex.
- Unravelling the Mechanism of N-Acetylcysteine in Alleviating Smoke-Induced Hypoxia-Driven Ocular Defects in Drosophila melanogaster.Molecular neurobiology · 2025Article
- Therapeutic evaluation of Martynia annua derived carbon dots in epileptic Drosophila model.Scientific reports · 2025Article
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- Chronic exposure to the star polycation (SPc) nanocarrier in the larval stage adversely impairs life history traits in Drosophila melanogaster.Journal of nanobiotechnology · 2022Article
- Functional Inactivation ofInternational journal of molecular sciences · 2021Article
- Nanocellulose-Based Biomedical Scaffolds in Future Bioeconomy: A Techno-Legal Assessment of the State-of-the-Art.Frontiers in bioengineering and biotechnology · 2021Review
- From Cellulose to Cellulose Nanofibrils-A Comprehensive Review of the Preparation and Modification of Cellulose Nanofibrils.Materials (Basel, Switzerland) · 2020Review
- An In Vitro Lung System to Assess the Proinflammatory Hazard of Carbon Nanotube Aerosols.International journal of molecular sciences · 2020Article
- Graphene Oxide Carboxymethylcellulose Nanocomposite for Dressing Materials.Materials (Basel, Switzerland) · 2020Article
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Corrections and comments
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wood-based cellulose nanofibrils (CNF) offer an excellent scaffold for drug-delivery formulation development. However, toxicity and haemocompatibility of the drug carrier is always an important issue. In this study, toxicity-related issues of CNF were addressed. Different doses of CNF were orally administered to Drosophila and different tests like the developmental cycle, trypan blue exclusion assay, larva crawling assay, thermal sensitivity assay, cold sensitivity assay, larval light preference test, climbing behaviour, nitroblue tetrazolium (NBT) reduction assay, adult phenotype, and adult weight were conducted to observe the impact on its development and behaviour. A haemocompatibility assay was done on the blood taken from healthy Wistar rats. In Drosophila, the abnormalities in larval development and behaviour were observed in the behavioural assays. However, the cytotoxic effect could not be confirmed by the gut staining and level of reactive oxygen species. The larvae developed into an adult without any abnormality in the phenotype. The CNF did cause loss of weight in the adult flies and did not cause much toxicity within the body since there was no phenotypic defect. Hemolysis data also suggested that CNF was safe at lower doses, as the data was well within acceptable limits. All these results suggest that cellulose nanofibres have no significant cytotoxic effects on Drosophila. However, the developmental and behavioural abnormalities suggest that CNF may act as a behavioural teratogen.
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Registered trials
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