ArticleThe Science of the total environment2019
Identifying hotspots for antibiotic resistance emergence and selection, and elucidating pathways to human exposure: Application of a systems-thinking approach to aquaculture systems.
Article in The Science of the total environment, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- PFK-158 enhances colistin efficacy against resistantFrontiers in veterinary science · 2026Article
- Systems thinking to understand the complexity of antimicrobial resistance across One Health: A systematic review of current approaches.One health (Amsterdam, Netherlands) · 2025Review
- Surveillance of Antimicrobial Resistance in the Asian Seabass (Foods (Basel, Switzerland) · 2025Article
- Antibiotics governance in aquaculture: knowledge, practices, and challenges among stakeholders on the Volta Lake in Ghana.One health outlook · 2025Article
- Rethinking the words hostspot reservoir and pristine in the environmental dimensions of antimicrobial resistance.npj antimicrobials and resistance · 2025Review
- Acquisition of novel antibiotic resistance genes by the bacterial predator Bacteriovorax sp. As-1.The ISME journal · 2025Article
- Emerging challenges in aquaculture: Current perspectives and human health implications.Veterinary world · 2025Review
- Short-term dynamics of fecal microbiome and antibiotic resistance in juvenile rainbow trout (Oncorhynchus mykiss) following antibiotic treatment and withdrawal.Animal microbiome · 2024Article
- Antimicrobial Resistance in Aquaculture: Risk Mitigation within the One Health Context.Foods (Basel, Switzerland) · 2024Review
- Review
- Hypolipidemic Effect of Rice Bran Oil Extract Tocotrienol in High-Fat Diet-Induced Hyperlipidemia Zebrafish (Danio Rerio) Induced by High-Fat Diet.International journal of molecular sciences · 2024Article
- Misunderstandings and misinterpretations: Antimicrobial use and resistance in salmon aquaculture.Environmental microbiology reports · 2023Article
- Quinolone Resistance Genes and Their Contribution to Resistance inAntibiotics (Basel, Switzerland) · 2023Article
- Antibiotic Resistance in the Finfish Aquaculture Industry: A Review.Antibiotics (Basel, Switzerland) · 2022Review
- Aquatic Environments as Hotspots of Transferable Low-Level Quinolone Resistance and Their Potential Contribution to High-Level Quinolone Resistance.Antibiotics (Basel, Switzerland) · 2022Review
- Antibiotic Resistance Properties amongMicroorganisms · 2022Article
- Article
- Article
- Metagenomic-based surveillance systems for antibiotic resistance in non-clinical settings.Frontiers in microbiology · 2022Review
- Systems-thinking approach to identify and assess feasibility of potential interventions to reduce antibiotic use in tilapia farming in Egypt.Aquaculture (Amsterdam, Netherlands) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors.
Funding
Abstract
Aquaculture systems are highly complex, dynamic and interconnected systems influenced by environmental, biological, cultural, socio-economic and human behavioural factors. Intensification of aquaculture production is likely to drive indiscriminate use of antibiotics to treat or prevent disease and increase productivity, often to compensate for management and husbandry deficiencies. Surveillance or monitoring of antibiotic usage (ABU) and antibiotic resistance (ABR) is often lacking or absent. Consequently, there are knowledge gaps for the risk of ABR emergence and human exposure to ABR in these systems and the wider environment. The aim of this study was to use a systems-thinking approach to map two aquaculture systems in Vietnam - striped catfish and white-leg shrimp - to identify hotspots for emergence and selection of resistance, and human exposure to antibiotics and antibiotic-resistant bacteria. System mapping was conducted by stakeholders at an interdisciplinary workshop in Hanoi, Vietnam during January 2018, and the maps generated were refined until consensus. Thereafter, literature was reviewed to complement and cross-reference information and to validate the final maps. The maps and component interactions with the environment revealed the grow-out phase, where juveniles are cultured to harvest size, to be a key hotspot for emergence of ABR in both systems due to direct and indirect ABU, exposure to water contaminated with antibiotics and antibiotic-resistant bacteria, and duration of this stage. The pathways for human exposure to antibiotics and ABR were characterised as: occupational (on-farm and at different handling points along the value chain), through consumption (bacterial contamination and residues) and by environmental routes. By using systems thinking and mapping by stakeholders to identify hotspots we demonstrate the applicability of an integrated, interdisciplinary approach to characterising ABU in aquaculture. This work provides a foundation to quantify risks at different points, understand interactions between components, and identify stakeholders who can lead and implement change.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.