ArticleCell reports2019
Microbial Exposure Enhances Immunity to Pathogens Recognized by TLR2 but Increases Susceptibility to Cytokine Storm through TLR4 Sensitization.
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Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
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85citing papers in PubMed
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Who cites it
85 citing papers in PubMed.
- Elevated Levels of Environmental Enteric Dysfunction Biomarkers Among Rural Indonesian Infants: Associations with Water, Sanitation, Hygiene and Linear Growth.Tropical medicine and infectious disease · 2026Article
- A gavage-fomite based method to generate mouse models with natural microbiota.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- A host-adapted commensal fungus from pet store mice drives type 2 immunity and cross-kingdom protection.iScience · 2026Article
- T-Cell Memory Affects Lung Responses to Cecal Ligation and Puncture.Shock (Augusta, Ga.) · 2026Article
- Sequential infection reprograms the immune landscape to shape future responses.bioRxiv : the preprint server for biology · 2026Article
- A gavage-fomite based method to generate mouse models with natural microbiota.bioRxiv : the preprint server for biology · 2026Article
- Diverse infection models demonstrate robust resistance ofbioRxiv : the preprint server for biology · 2026Article
- Basophils drive the resolution and promote wound healing in adult and aged mice.The Journal of experimental medicine · 2026Article
- Bone marrow and splenic immune composition is unperturbed by short-term exposure to bedding from pet store mice.ImmunoHorizons · 2026Article
- Optimization of Preclinical Rodent Research Models of Human Shock: Part One Intra-Abdominal Sepsis.Shock (Augusta, Ga.) · 2026Review
- Diverse Microbial Exposure Enhances CD8bioRxiv : the preprint server for biology · 2026Article
- IL17FMolecular medicine (Cambridge, Mass.) · 2026Article
- A host-adapted commensal fungus from pet store mice drives type 2 immunity and cross-kingdom protection.bioRxiv : the preprint server for biology · 2026Article
- A large-scale concordance study of toxicity findings across preclinical species and humans for small molecules and biologics.Frontiers in toxicology · 2026Article
- Naturalized immune responses are stable over years in a colony of laboratory mice with wild-derived microbiota.Immunity · 2025Article
- Physiological microbial exposure normalizes memory T cell surveillance of the brain and modifies host seizure outcomes.Nature immunology · 2025Article
- Lifelong partners: Gut microbiota-immune cell interactions from infancy to old age.Mucosal immunology · 2025Review
- Epidemiology of Parvovirus B19 in Türkiye: A Descriptive Analysis of National Surveillance Data (2020-2024).Balkan medical journal · 2025Article
- Integrating natural commensals and pathogens into preclinical mouse models.Nature reviews. Immunology · 2025Review
- Rewilding catalyzes maturation of the humoral immune system.Science advances · 2025Article
25 more citing papers are in PubMed but not listed here.
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Authors and funding
16 authors.
Matthew A HugginsDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
Frances V SjaastadMicrobiology, Immunology, and Cancer Biology PhD Program, University of Minnesota, Minneapolis, MN, USA.
Mark PiersonDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
Tamara A KucabaDepartment of Urology, University of Minnesota, Minneapolis, MN, USA.
Whitney SwansonDepartment of Urology, University of Minnesota, Minneapolis, MN, USA.
Christopher StaleyDepartment of Surgery, University of Minnesota, Minneapolis, MN, USA.
Alexa R WeingardenDepartment of Soil, Water, and Climate and The BioTechnology Institute, University of Minnesota, St. Paul, MN, USA.
Isaac J JensenInterdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA, USA.
Derek B DanahyInterdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA, USA.
Vladimir P BadovinacInterdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA, USA; Department of Pathology, University of Iowa, Iowa City, IA, USA; Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA.
Stephen C JamesonDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA; Microbiology, Immunology, and Cancer Biology PhD Program, University of Minnesota, Minneapolis, MN, USA; Center for Immunology, University of Minnesota, Minneapolis, MN, USA; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
Vaiva VezysMicrobiology, Immunology, and Cancer Biology PhD Program, University of Minnesota, Minneapolis, MN, USA; Center for Immunology, University of Minnesota, Minneapolis, MN, USA; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, USA.
David MasopustMicrobiology, Immunology, and Cancer Biology PhD Program, University of Minnesota, Minneapolis, MN, USA; Center for Immunology, University of Minnesota, Minneapolis, MN, USA; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, USA.
Alexander KhorutsMicrobiology, Immunology, and Cancer Biology PhD Program, University of Minnesota, Minneapolis, MN, USA; Center for Immunology, University of Minnesota, Minneapolis, MN, USA; Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
Thomas S GriffithMicrobiology, Immunology, and Cancer Biology PhD Program, University of Minnesota, Minneapolis, MN, USA; Department of Urology, University of Minnesota, Minneapolis, MN, USA; Center for Immunology, University of Minnesota, Minneapolis, MN, USA; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA; Minneapolis VA Health Care System, Minneapolis, MN, USA. Electronic address: tgriffit@umn.edu.
Sara E HamiltonDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA; Microbiology, Immunology, and Cancer Biology PhD Program, University of Minnesota, Minneapolis, MN, USA; Center for Immunology, University of Minnesota, Minneapolis, MN, USA; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA. Electronic address: hamil062@umn.edu.
Funding
Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Jeffrey S. Miller · 1998 to 2026
$100.4MTRAINING GRANT IN MICROBIOLOGY/CANCER RESEARCHT32CA009138 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Scott M. Dehm · 1985 to 2026
$11.3MTRAINING IN MECHANISMS OF PARASITISMT32AI007511 · NIAID · UNIVERSITY OF IOWA · PI BUTLER, NOAH SULLIVAN, WEBER, MARY · 1996 to 2025
$8.1MIMMUNOLOGY TRAINING PROGRAMT32AI007313 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Carla Rothlin · 1989 to 2026
$5.7MPREDOCTORAL TRAINING PROGRAM IN IMMUNOLOGYT32AI007485 · NIAID · UNIVERSITY OF IOWA · PI Kevin L Legge · 1995 to 2026
$5.4MRegulation of the Immune Response to Plasmodium by IL-10 Producing Natural Killer CellsR01AI143828 · NIAID · UNIVERSITY OF MINNESOTA · PI HAMILTON HART, SARA ELIZABETH · 2019 to 2023
$2.3MGeneration and function of "long-lived effector" memory CD8 T cellsR01AI116678 · NIAID · UNIVERSITY OF MINNESOTA · PI HAMILTON HART, SARA ELIZABETH · 2015 to 2019
$2.3MAlterations in CD4 T cells during sepsisR01GM115462 · NIGMS · UNIVERSITY OF MINNESOTA · PI GRIFFITH, THOMAS S · 2016 to 2019
$1.2MImpairment and recovery of CD8 T cell responses after sepsisR01GM113961 · NIGMS · UNIVERSITY OF IOWA · PI BADOVINAC, VLADIMIR P · 2015 to 2018
$1.2MUsing microbially-experienced mice to study the innate immune response in sepsisI01BX001324 · VA · MINNEAPOLIS VA MEDICAL CENTER · PI GRIFFITH, THOMAS S · 2013 to 2025
–BLRD VA I01 BX001324NCI NIH HHS P30 CA077598NCI NIH HHS T32 CA009138NIAID NIH HHS R01 AI116678NIAID NIH HHS R01 AI143828NIAID NIH HHS T32 AI007313NIAID NIH HHS T32 AI007485NIAID NIH HHS T32 AI007511NIGMS NIH HHS R01 GM113961NIGMS NIH HHS R01 GM115462
Abstract
Microbial exposures can define an individual's basal immune state. Cohousing specific pathogen-free (SPF) mice with pet store mice, which harbor numerous infectious microbes, results in global changes to the immune system, including increased circulating phagocytes and elevated inflammatory cytokines. How these differences in the basal immune state influence the acute response to systemic infection is unclear. Cohoused mice exhibit enhanced protection from virulent Listeria monocytogenes (LM) infection, but increased morbidity and mortality to polymicrobial sepsis. Cohoused mice have more TLR2
Indexed as
AnimalsCytokinesFemaleImmunity, InnateInflammationListeria monocytogenesListeriosisMacrophagesMiceMice, Inbred C57BLPhagocytesSepsisToll-Like Receptor 2Toll-Like Receptor 4CytokinesTlr2 protein, mouseTlr4 protein, mouseToll-Like Receptor 2Toll-Like Receptor 4infectionListeria monocytogenesmicrobiomephysiological microbial exposurepolymicrobial sepsisToll-like receptors
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.