Evidence map›Paper›PMID 31412242›Full record

Trial reportCell reports2019

Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD

Yasir S Elhassan, Katarina Kluckova, Rachel S Fletcher, Mark S Schmidt, Antje Garten, Craig L Doig, David M Cartwright, Lucy Oakey, Claire V Burley, Ned Jenkinson and 12 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05684367 (Center-Based and Home-Based Walking Exercise Intervention to Reduce Fatigue in Older Breast Cancer Survivors), which is not on this map. Cited by 289 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
289citing papers in PubMed, 7 pooled it
25.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05684367 narecruitingnot on this mapstarted 2023, after this paper: background citation

Center-Based and Home-Based Walking Exercise Intervention to Reduce Fatigue in Older Breast Cancer Survivors

TypeinterventionalSponsorUniversity of FloridaRan2023 to 2026Enrolled24ConditionsFatigue, Breast Cancer, Cancer, Therapy-RelatedArmsCenter-Based Walking Exercise, Home-Based Walking Exercise
3 · Its place in the literature

Who cites it

289 citing papers in PubMed, 7 syntheses or guidelines pooled it, 416 citations in OpenAlex.

  1. Domain-specific effects of NADFrontiers in nutrition · 2026
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  13. Effects of NADThe Journal of pharmacology and experimental therapeutics · 2025
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229 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 6 institutions in 3 countries.

Yasir S ElhassanInstitute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK; MRC-Arthritis Research UK Centre for Musculoskeletal Ageing Research, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.
Katarina KluckovaInstitute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.
Rachel S FletcherInstitute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.
Mark S SchmidtDepartment of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Antje GartenInstitute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.
Craig L DoigInstitute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.
David M CartwrightInstitute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.
Lucy OakeyInstitute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.
Claire V BurleySchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK; Centre for Human Brain Health, University of Birmingham, Birmingham, UK.
Ned JenkinsonSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK; Centre for Human Brain Health, University of Birmingham, Birmingham, UK.
Martin WilsonCentre for Human Brain Health, University of Birmingham, Birmingham, UK; School of Psychology, University of Birmingham, Birmingham, UK.
Samuel J E LucasSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK; Centre for Human Brain Health, University of Birmingham, Birmingham, UK.
Ildem AkermanInstitute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.
Alex SeabrightSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK.
Yu-Chiang LaiSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK.
Daniel A TennantInstitute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.
Peter NightingaleInstitute of Translational Medicine, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Gareth A WallisSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK.
Konstantinos N ManolopoulosInstitute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK.
Charles BrennerDepartment of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Andrew PhilpSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK; Diabetes and Metabolism Division, Garvan Institute of Medical Research, Sydney, NSW, Australia; Faculty of Medicine, St. Vincent's Clinical School, Sydney, UNSW, Australia.
Gareth G LaveryInstitute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK; MRC-Arthritis Research UK Centre for Musculoskeletal Ageing Research, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK. Electronic address: g.g.lavery@bham.ac.uk.
University of Birmingham · GBBirmingham City University · GBUniversity of Iowa · USGarvan Institute of Medical Research · AUNIHR Birmingham Biomedical Research Centre · GBUniversity Hospitals Birmingham NHS Foundation Trust · GB

Funding

The SIRT1-Gpd1L-NAD+ interactome in regulation of the Neuronal Sodium Channel: Implications for Cognitive Impairment of Alzheimer’s DementiaR01HL147545 · NHLBI · UNIVERSITY OF IOWA · PI BRENNER, CHARLES M, IRANI, KAIKOBAD J. · 2019 to 2022
$2.9M
Arthritis Research UKMedical Research Council MC_PC_15032NHLBI NIH HHS R01 HL147545Wellcome TrustWellcome Trust 104612/Z/14/Z
6 · The paper itself

Abstract

Nicotinamide adenine dinucleotide (NAD

Indexed as

AgedAged, 80 and overAgingAnti-Inflammatory AgentsCross-Sectional StudiesCytokinesDouble-Blind MethodHumansMaleMetabolomeMuscle, SkeletalNADNiacinamidePyridinium CompoundsTranscriptomeAnti-Inflammatory AgentsCytokinesNADNiacinamidenicotinamide-beta-ribosidePyridinium Compoundsagingcell adhesioninflammationmetabolismnicotinamide adenine dinucleotide

Identifiers

PMID31412242
PMCPMC6702140
OpenAlexW2968217662

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.