ArticlePloS one2019
Early-life dentine manganese concentrations and intrinsic functional brain connectivity in adolescents: A pilot study.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Toxicant exposure and the developing brain: A systematic review of the structural and functional MRI literature.Neuroscience and biobehavioral reviews · 2023Pooled it
- Dentin Metal and Trace Elements in Deciduous Teeth: Findings from Project Viva.Environmental science & technology · 2025Article
- Exploring the Neural Correlates of Metal Exposure in Motor Areas.Brain sciences · 2025Review
- Children's exposure to chemical contaminants: Demographic disparities and associations with the developing basal ganglia.Environmental research · 2024Article
- Early-Life Critical Windows of Susceptibility to Manganese Exposure and Sex-Specific Changes in Brain Connectivity in Late Adolescence.Biological psychiatry global open science · 2023Article
- Environmental Toxicants and the Developing Brain.Biological psychiatry · 2023Review
- Equine odontoclastic tooth resorption and hypercementosis (EOTRH): microspatial distribution of trace elements in hypercementosis-affected and unaffected hard dental tissues.Scientific reports · 2023Article
- Associations between Elemental Metabolic Dynamics and Default Mode Network Functional Connectivity Are Altered in Autism.Journal of clinical medicine · 2023Article
- Neuro-environmental interactions: a time sensitive matter.Frontiers in computational neuroscience · 2023Article
- Topological network properties of resting-state functional connectivity patterns are associated with metal mixture exposure in adolescents.Frontiers in neuroscience · 2023Article
- The NIH ECHO Program: investigating how early environmental influences affect child health.Pediatric research · 2022Article
- Association between Long-Term Air Pollution, Chronic Traffic Noise, and Resting-State Functional Connectivity in the 1000BRAINS Study.Environmental health perspectives · 2022Article
- Differences and Interactions in Placental Manganese and Iron Transfer across an In Vitro Model of Human Villous Trophoblasts.International journal of molecular sciences · 2022Article
- Pediatric Exposures to Neurotoxicants: A Review of Magnetic Resonance Imaging and Spectroscopy Findings.Diagnostics (Basel, Switzerland) · 2022Review
- Interaction of Blood Manganese Concentrations with GSTT1 in Relation to Autism Spectrum Disorder in Jamaican Children.Journal of autism and developmental disorders · 2021Article
- Associations between a metal mixture and infant negative affectivity: Effect modification by prenatal cortisol and infant sex.Child developmentArticle
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Authors and funding
13 authors at 5 institutions in 3 countries.
Funding
Abstract
Maturational processes in the developing brain are disrupted by exposure to environmental toxicants, setting the stage for deviant developmental trajectories. Manganese (Mn) is an essential nutrient that is neurotoxic at high levels of exposure, particularly affecting the basal ganglia and prefrontal cortex. Both the intensity and timing of exposure matter; deciduous teeth can be used to retrospectively and objectively determine early-life windows of vulnerability. The aim of this pilot study was to examine associations between prenatal, early postnatal and childhood dentine Mn concentrations and intrinsic functional connectivity (iFC) of adolescents' brains. 14 adolescents (12-18 years; 6 girls) from northern Italian regions with either current, historic or no Mn contamination, completed a 10-minute resting state functional Magnetic Resonance Imaging (MRI) scan in an 1.5T MRI scanner. We estimated prenatal, early postnatal and childhood Mn concentrations in deciduous teeth using laser ablation-inductively coupled plasma-mass spectrometry. We performed seed-based correlation analyses, focusing on six subcortical seeds (left and right caudate, putamen, pallidum) and one cortical seed (bilateral middle frontal gyrus) from Harvard-Oxford atlases. We examined linear and quadratic correlations between log-transformed Mn concentrations and seed-based iFC (Bonferroni-corrected p<0.0023), controlling for either socio-economic status, sex or age. Dentine Mn concentrations (Mn:Calcium ratio) were highest during the prenatal period (median = 0.48) and significantly declined during the early postnatal (median = 0.14) and childhood periods (median = 0.006). Postnatal Mn concentrations were associated with: 1) increased iFC between the middle frontal gyrus and medial prefrontal cortex; 2) decreased iFC between the right putamen and pre- and postcentral gyrus. Together, these findings suggest that early postnatal Mn concentrations are associated with increased iFC within cognitive control brain areas, but decreased iFC between motor areas in adolescents. Future studies should replicate these findings in larger samples, and link brain connectivity measures to cognitive and motor outcomes.
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