Evidence map›Paper›PMID 31412042›Full record

ArticlePloS one2019

The relationship between plasma amino acids and circulating albumin and haemoglobin in postabsorptive stroke patients.

Roberto Aquilani, Roberto Maestri, Mirella Boselli, Maria Pia Achilli, Nadia Arrigoni, Mariella Bruni, Maurizia Dossena, Manuela Verri, Daniela Buonocore, Evasio Pasini and 2 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04459091 (Effects of Supplementation With Amino Essential Acids on Circulating Albumin Levels in Patients With Cerebral Ictus in Rehabilitation Phase), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04459091 nacompletednot on this map

Effects of Supplementation With Amino Essential Acids on Circulating Albumin Levels in Patients With Cerebral Ictus in Rehabilitation Phase

TypeinterventionalSponsorIstituti Clinici Scientifici Maugeri SpARan2018 to 2018Enrolled125ConditionsStroke RehabilitationArmsAmino Essential Acid, placebo
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Roberto AquilaniDipartimento di Biologia e Biotecnologie Università degli Studi di Pavia, Italy.
Roberto MaestriIstituti Clinici Scientifici Maugeri IRCCS, Servizio di Bioingegneria, Istituto di Montescano, Montescano, Pavia, Italy.
Mirella BoselliIstituti Clinici Scientifici Maugeri IRCCS, Unita di Riabilitazione Neuromotoria, Unita Gravi Cerebrolesioni Acquisite, Istituto di Montescano, Montescano, Pavia, Italy.
Maria Pia AchilliIstituti Clinici Scientifici Maugeri IRCCS, Unita di Riabilitazione Neuromotoria, Unita Gravi Cerebrolesioni Acquisite, Istituto di Montescano, Montescano, Pavia, Italy.
Nadia ArrigoniIstituti Clinici Scientifici Maugeri IRCCS, Unita di Riabilitazione Neuromotoria, Unita Gravi Cerebrolesioni Acquisite, Istituto di Montescano, Montescano, Pavia, Italy.
Mariella BruniIstituti Clinici Scientifici Maugeri IRCCS, Servizio di Patologia Clinica, Istituto di Pavia, Pavia, Italy.
Maurizia DossenaDipartimento di Biologia e Biotecnologie Università degli Studi di Pavia, Italy.
Manuela VerriDipartimento di Biologia e Biotecnologie Università degli Studi di Pavia, Italy.
Daniela BuonocoreDipartimento di Biologia e Biotecnologie Università degli Studi di Pavia, Italy.
Evasio PasiniIstituti Clinici Scientifici Maugeri, IRCCS, Divisione di Riabilitazione Cardiologica, Istituto di Lumezzane, Lumezzane, Bergamo, Italy.
Annalisa BarbieriDipartimento di Scienze del Farmaco, Università degli Studi di Pavia, Italy.
Federica BoschiDipartimento di Scienze del Farmaco, Università degli Studi di Pavia, Italy.ORCID 0000-0002-3192-6397
Istituti Clinici Scientifici Maugeri · ITUniversity of Pavia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis retrospective study had two main aims: (1) to document possible correlations between plasma Amino Acids (AAs) and circulating Albumin (Alb) and Haemoglobin (Hb); and (2) to identify which AAs were predictors of Alb and Hb.

methodsThe study considered 125 stroke subjects (ST) (61.6% males; 65.6 +/- 14.9 years) who met the eligibility criteria (absence of co morbidities associated with altered plasma AAs and presence of plasma AAs determined after overnight fasting). Fifteen matched healthy subjects with measured plasma AAs served as controls.

resultsThe best correlations of Alb were with tryptophan (Trp) and histidine (His) (r = + 0.53; p < 0.0001), and those of Hb were with histidine (r = +0.47) and Essential AAs (r = +0.47) (both p<0.0001). In multivariate analysis, Trp (p< 0.0001) and His (p = 0.01) were shown to be the best positive predictors of Alb, whereas glutamine (p = 0.006) was the best positive predictor of Hb.

conclusionsThe study shows that the majority of plasma AAs were positively correlated with Alb and Hb. The best predictors of circulating Alb and Hb were the levels of tryptophan and glutamine, respectively.

Indexed as

AgedAmino AcidsCase-Control StudiesFemaleHemoglobinsHumansMalePrognosisRetrospective StudiesSerum AlbuminStrokeAmino AcidsHemoglobinsSerum Albumin

Identifiers

PMID31412042
PMCPMC6693779
OpenAlexW2969168662

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.