ArticlePLoS neglected tropical diseases2019
Crosstalk between leukocytes triggers differential immune responses against Salmonella enterica serovars Typhi and Paratyphi.
Article in PLoS neglected tropical diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
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- Harnessing adjuvant-induced epigenetic modulation for enhanced immunity in vaccines and cancer therapy.Frontiers in immunology · 2025Review
- Early host immune responses in a human organoid-derived gallbladder monolayer toFrontiers in immunology · 2024Article
- Epigenetic regulation in epithelial cells and innate lymphocyte responses toFrontiers in immunology · 2024Article
- The Yin and Yang of pathogens and probiotics: interplay betweenFrontiers in microbiology · 2024Article
- Early transcriptional responses to human enteric fever challenge.Infection and immunity · 2023Article
- Secretory-IgA binding to intestinal microbiota attenuates inflammatory reactions as the intestinal barrier of preterm infants matures.Clinical and experimental immunology · 2023Article
- Mucosal-Associated Invariant T cells exhibit distinct functional signatures associated with protection against typhoid fever.Cellular immunology · 2022Article
- Salmonella enterica serovar Typhi influences inflammation and autophagy in macrophages.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022Article
- Host restriction, pathogenesis and chronic carriage of typhoidal Salmonella.FEMS microbiology reviews · 2021Review
- Antimicrobial Susceptibility Pattern ofInfectious disease reports · 2021Article
- B Cells Control Mucosal-Associated Invariant T Cell Responses toFrontiers in immunology · 2021Article
- New Insights on the Early Interaction Between Typhoid and Non-typhoidFrontiers in microbiology · 2021Review
- Spheres of Influence: Insights intoMicroorganisms · 2020Review
- Differential functional patterns of memory CD4Vaccine · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Enteric fevers, caused by the Salmonella enterica serovars Typhi (ST), Paratyphi A (PA) and Paratyphi B (PB), are life-threatening illnesses exhibiting very similar clinical symptoms but with distinct epidemiologies, geographical distributions and susceptibilities to antimicrobial treatment. Nevertheless, the mechanisms by which the host recognizes pathogens with high levels of homology, such as these bacterial serovars, remain poorly understood. Using a three-dimensional organotypic model of the human intestinal mucosa and PA, PB, and ST, we observed significant differences in the secretion patterns of pro-inflammatory cytokines and chemokines elicited by these serovars. These cytokines/chemokines were likely to be co-regulated and influenced the function of epithelial cells, such as the production of IL-8. We also found differing levels of polymorphonuclear leukocyte (PMN) migration among various infection conditions that either included or excluded lymphocytes and macrophages (Mϕ), strongly suggesting feedback mechanisms among these cells. Blocking experiments showed that IL-1β, IL-6, IL-8, TNF-α and CCL3 cytokines were involved in the differential regulation of migration patterns. We conclude that the crosstalk among the lymphocytes, Mϕ, PMN and epithelial cells is cytokine/chemokine-dependent and bacterial-serotype specific, and plays a pivotal role in orchestrating the functional efficiency of the innate cells and migratory characteristics of the leukocytes.
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