ArticleJournal of neurophysiology2019
Animal models of developmental motor disorders: parallels to human motor dysfunction in cerebral palsy.
Article in Journal of neurophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 43 citations in OpenAlex.
- Infantile Cocktail of Erythropoietin and Melatonin Restores Gait in Adult Rats with Preterm Brain Injury.Developmental neuroscience · 2022Trial
- Modeling cerebral palsy in animals.Developmental medicine and child neurology · 2026Review
- A low-cost, open-source device to evaluate limb stiffness in a rabbit model of cerebral palsy.Frontiers in bioengineering and biotechnology · 2025Article
- Construction and Behavioral Comparison of Two Mouse Models of Cerebral Palsy.Bulletin of experimental biology and medicine · 2024Article
- The RhoB p.S73F mutation leads to cerebral palsy through dysregulation of lipid homeostasis.EMBO molecular medicine · 2024Article
- Electroacupuncture activates the peroxisome proliferators-activated receptor pathway to improve the phenotype of cerebral palsy.CNS neuroscience & therapeutics · 2024Article
- Air-stepping in the neonatal mouse: a powerful tool for analyzing early stages of rhythmic limb movement development.Journal of neurophysiology · 2024Article
- Spinal motoneurons respond aberrantly to serotonin in a rabbit model of cerebral palsy.The Journal of physiology · 2023Article
- Beyond TORCH: A narrative review of the impact of antenatal and perinatal infections on the risk of disability.Neuroscience and biobehavioral reviews · 2023Review
- Inhibitory Synaptic Influences on Developmental Motor Disorders.International journal of molecular sciences · 2023Review
- Spinal motoneurons respond aberrantly to serotonin in a rabbit model of cerebral palsy.bioRxiv : the preprint server for biology · 2023Article
- Early-stage effect of HIBD on neuro-motor function and organic composition of neurovascular units in neonatal rats.Frontiers in neuroscience · 2023Article
- The left-right side-specific endocrine signaling: implications for neurological deficits in stroke and neurodevelopmental disorders.Neural regeneration research · 2022Article
- Enhanced nociceptive behavior and expansion of associated primary afferents in a rabbit model of cerebral palsy.Journal of neuroscience research · 2022Article
- Trans-Spinal Direct Current Stimulation Targets CaFrontiers in neuroscience · 2022Article
- Neutrophil-to-lymphocyte ratio predicts the severity of motor impairment in cerebral palsy children living at home and the rehabilitation center: A comparative study.Biomedical reports · 2020Article
- Muscle Microbiopsy to Delineate Stem Cell Involvement in Young Patients: A Novel Approach for Children With Cerebral Palsy.Frontiers in physiology · 2020Article
- Altered Motoneuron Properties Contribute to Motor Deficits in a Rabbit Hypoxia-Ischemia Model of Cerebral Palsy.Frontiers in cellular neuroscience · 2020Article
- Maturation of the Locomotor Circuitry in Children With Cerebral Palsy.Frontiers in bioengineering and biotechnology · 2020Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Cerebral palsy (CP) is the most common motor disability in children. Much of the previous research on CP has focused on reducing the severity of brain injuries, whereas very few researchers have investigated the cause and amelioration of motor symptoms. This research focus has had an impact on the choice of animal models. Many of the commonly used animal models do not display a prominent CP-like motor phenotype. In general, rodent models show anatomically severe injuries in the central nervous system (CNS) in response to insults associated with CP, including hypoxia, ischemia, and neuroinflammation. Unfortunately, most rodent models do not display a prominent motor phenotype that includes the hallmarks of spasticity (muscle stiffness and hyperreflexia) and weakness. To study motor dysfunction related to developmental injuries, a larger animal model is needed, such as rabbit, pig, or nonhuman primate. In this work, we describe and compare various animal models of CP and their potential for translation to the human condition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.