ArticlePhytochemical analysis : PCA2021
Quality evaluation of Lonicerae Japonicae Flos and Lonicerae Flos based on simultaneous determination of multiple bioactive constituents combined with multivariate statistical analysis.
Article in Phytochemical analysis : PCA, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Review
- Environmental Shaping Suitable Habitats and Quality ofPlants (Basel, Switzerland) · 2026Article
- A Network Pharmacology and Experimental Validation Strategy for Hypoglycemic Study of Lonicerae Japonicae Flos on Diabetes.Journal of cellular and molecular medicine · 2026Article
- Dynamic Chemical Profiling ofFoods (Basel, Switzerland) · 2026Article
- A Diboronic Acid-Based Fluorescent Sensor Array for Rapid Identification of Lonicerae Japonicae Flos and Lonicerae Flos.Molecules (Basel, Switzerland) · 2024Article
- Metabolomics distinguishes different grades ofHeliyon · 2024Article
- Cuproptosis-Related lncRNA Predict Prognosis and Immune Response of LUAD.Pharmacogenomics and personalized medicine · 2024Article
- Comparative analysis of chloroplast genome ofOpen life sciences · 2024Article
- Classification and Authentication of Lonicerae Japonicae Flos and Lonicerae Flos by UsingMolecules (Basel, Switzerland) · 2023Article
- Article
- Quality evaluation of Lonicerae Japonicae Flos and Lonicerae Flos based on simultaneous determination of multiple bioactive constituents combined with multivariate statistical analysis.Phytochemical analysis : PCA · 2021Article
- Potential Application ofFrontiers in microbiology · 2021Review
- Comparative Analysis of Free Amino Acids and Nucleosides in Different Varieties of Mume Fructus Based on Simultaneous Determination and Multivariate Statistical Analyses.International journal of analytical chemistry · 2020Article
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Authors and funding
8 authors.
Funding
Abstract
introductionLonicerae Japonicae Flos (LJF) and Lonicerae Flos (LF) belong to different genera of Caprifoliaceae. They have been historically utilised as herbal medicine to treat various diseases. However, the comprehensive assessment of them still remains a challenge.
objectiveTo develop a comprehensive method of ultra-fast liquid chromatography-tandem triple quadrupole mass spectrometry (UFLC-QTRAP-MS/MS) coupled with multivariate statistical analysis for the quality evaluation and reveal differential components of LJF and LF. METHODOLOGY: A validated UFLC-QTRAP-MS/MS method was established for simultaneous determination of 50 constituents, including 12 organic acids, 12 flavonoids, 6 iridoids, 3 saponins, 13 amino acids and 4 nucleosides. The obtained data were employed to multivariate statistical analysis. Principal component anlysis (PCA) and partial least squares determinant analysis (PLS-DA) were performed to classify and reveal differential components of samples; grey relational analysis (GRA) was introduced to assess the samples according to the contents of 50 constituents by calculating the relative correlation degree of each sample.
resultsFifty constituents were simultaneously determined of LJF and LF. Based on obtained data, PCA and PLS-DA were easy to distinguish samples and the classification of the samples was related to 11 chemical constituents. GRA implied the quality of LJF was better, and that the flower buds were superior to the flowers. Moreover, organic acids are the main components of samples.
conclusionThis study not only established a method of simultaneous determination of multiple bioactive constituents in LJF and LF, but provided comprehensive information on the quality control of them. The developed method is conducive to distinguish orthologues or paralogues of them, and supply the support for "heterologous effects".
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