ArticleJournal of the American Geriatrics Society2019
The Association Between Low-Density Lipoprotein Cholesterol and Incident Atherosclerotic Cardiovascular Disease in Older Adults: Results From the National Institutes of Health Pooled Cohorts.
Article in Journal of the American Geriatrics Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 45 citations in OpenAlex.
- Cardiovascular Events in US Adults Aged ≥80 Years: Incidence, Risk Factors, and Outcomes.Circulation. Population health and outcomes · 2026Article
- Low-density lipoprotein cholesterol and clinical outcomes in patients with liver cirrhosis: a nationwide cohort study.Annals of medicine · 2025Article
- Older Than You Think-The Psychology of Comparison.JAMA cardiology · 2025Article
- Cholesterol Levels and Cardiovascular Outcomes Following Statin Initiation for Primary Prevention: A Cohort Study.JACC. Advances · 2025Article
- Cholesterol Lowering in Older Adults: Should We Wait for Further Evidence?Current atherosclerosis reports · 2024Review
- Treating Hypercholesterolemia in Older Adults for Primary Prevention of Cardiovascular Events.Drugs & aging · 2024Review
- The role of statin therapy in older adults: best practices and unmet challenges.Expert review of cardiovascular therapy · 2024Review
- Detraining and Retraining Effects from a Multicomponent Training Program on the Functional Capacity and Health Profile of Physically Active Prehypertensive Older Women.Healthcare (Basel, Switzerland) · 2024Article
- Follow-Up of Eight-Weeks Detraining Period after Exercise Program on Health Profiles of Older Women.Healthcare (Basel, Switzerland) · 2023Article
- Life's Essential 8: Optimizing Health in Older Adults.JACC. Advances · 2023Article
- Article
- The hospital care experiences of older patients compared to younger patients.Journal of the American Geriatrics Society · 2022Article
- Use of statins and associated factors in nonagenarians in the Community of Madrid, Spain.Aging clinical and experimental research · 2022Observational
- Effects of low-density lipoprotein cholesterol on cardiovascular disease and all-cause mortality in elderly patients (≥75 years old).Endocrine · 2022Article
- Testosterone Level Reduction Increases the 10-Year Risk of Cardiovascular Diseases: A Retrospective Cohort Study in a Taiwanese Young Male Population.Frontiers in cardiovascular medicine · 2022Article
- Article
- Admission LDL-C and long-term mortality in patients with acute aortic dissection: a survival analysis in China.Annals of translational medicine · 2021Article
- Association between lipoprotein cholesterol and future cardiovascular disease and mortality in older adults: a Korean nationwide longitudinal study.Lipids in health and disease · 2021Article
- [Statement of the Spanish Interdisciplinary Vascular Prevention Committee on the updated European Cardiovascular Prevention Guidelines.]Revista espanola de salud publica · 2020Review
- Ezetimibe promotes CYP7A1 and modulates PPARs as a compensatory mechanism in LDL receptor-deficient hamsters.Lipids in health and disease · 2020Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
BACKGROUND/
objectivesElevated low-density lipoprotein cholesterol (LDL-C) in early adulthood is associated with increased risk of atherosclerotic cardiovascular disease (ASCVD). The strength of the association between LDL-C and ASCVD among older adults, however, is less understood.
designWe examined individual-level cohort data from the National Institutes of Health Pooled Cohorts (Framingham Study, Framingham Offspring Study, Multi-Ethnic Study of Atherosclerosis, and Cardiovascular Health Study), which prospectively measured CVD risk factors and incident disease.
settingProspective cohort study.
participantsAdults, aged 75 years or older, free of ASCVD. MEASUREMENTS: We evaluated the associations between LDL-C and incident ASCVD (stroke, myocardial infarction, and cardiovascular death) in unadjusted analysis and in multivariable-adjusted Cox proportional hazards models. We assessed 5-year Kaplan-Meier ASCVD event rates in patients with and without hyperlipidemia (LDL-C ≥130 mg/dL or on lipid-lowering medications), stratified by the number of other risk factors, including smoking, diabetes, and hypertension.
resultsWe included 2667 adults, aged 75 years or older (59% female), free of ASCVD; median age was 78 years, with median LDL-C of 117 mg/dL. In both unadjusted and adjusted analyses, there was no association between LDL-C and ASCVD (adjusted hazard ratio = 1.022; 95% confidence interval = 0.998-1.046; P = .07). Among adults without other risk factors (free of smoking, diabetes, and hypertension), event rates were similar between those with and without hyperlipidemia (Kaplan-Meier rates = 5.8% and 7.0%, respectively). Among adults with one or two or more other risk factors, the presence of hyperlipidemia was also not associated with 5-year CVD event rates (Kaplan-Meier rates = 12.8% vs 15.0% [P = .44] for one other risk factor and 21.9% vs 24.0% [P = .59] for two or more other risk factors).
conclusionAmong a well-characterized cohort, LDL-C was not associated with CVD risk among adults aged 75 years or older, even in the presence of other risk factors. J Am Geriatr Soc 67:2560-2567, 2019.
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